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Gusacitinib - 98%, high purity , CAS No.1425381-60-7, Inhibitor of Janus kinase 2;Inhibitor of spleen associated tyrosine kinase
Basic Description Synonyms Gusacitinib|1425381-60-7|ASN-002|ASN002|Gusacitinib [INN]|Gusacitinib [USAN]|EN3351|Gusacitinib [USAN:INN]|4801QYW816|EN-3351|UNII-4801QYW816|WHO 10976|2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acet Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Gusacitinib (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 of 5-46 nM. Gusacitinib has anti-cancer activity. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of Janus kinase 2;Inhibitor of spleen associated tyrosine kinase Product Description Information
Gusacitinib (ASN-002) is an orally active and potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 of 5-46 nM. Gusacitinib has anti-cancer activity.
Names and Identifiers IUPAC Name 2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile INCHI InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29) InChi Key NLFLXLJXEIUQDL-UHFFFAOYSA-N Canonical SMILES C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O Isomeric SMILES C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O Alternate CAS 1425381-60-7 PubChem CID 71269142 MeSH Entry Terms 1-(4-(4-(4-hydroxy-piperidin-1-yl)-phenylamino)-5-oxo-5,6-dihydro-pyrimido(4,5-D)pyridazin-2-yl)-piperidin-4-YL-acetonitrile;4-piperidineacetonitrile, 1-(5,6-dihydro-4-((4-(4-hydroxy-1-piperidinyl)phenyl)amino)-5-oxopyrimido(4,5-D)pyridazin-2-yl)-;ASN-002 Molecular Weight 460.53
References 1. He H, Guttman-Yassky E. (2019) JAK Inhibitors for Atopic Dermatitis: An Update.. Am J Clin Dermatol, 20 (2): (181-192). [PMID:30536048 ]
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B2402616