| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| G654715-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $219.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In | Dry ice |
| Product Description | GW 590735 is a potent and selective PPARα agonist. GW 590735 shows EC 50 =4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW 590735 can be used for the research of dyslipidemia. In Vivo GW 590735 (0.5-5 mg/kg; orally twice a day for 5 days) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol in the Apo-A-I-transgenic mouse model (male C57BL/6 mice transgenic for human ApoA-I) . GW 590735 (intravenous administration; 2.7 mg/kg; rat) treatment shows Cl, Vd, T 1/2 , and F % are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively . GW 590735 (intravenous administration; 2 mg/kg; dog) treatment shows Cl, Vd, T 1/2 , and F % are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Canonical SMILES | OC(C(C)(C)OC(C=C1)=CC=C1CNC(C2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=O)=O |
|---|---|
| Molecular Weight | 478.48 |
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