Discover GW4869 by Aladdin Scientific in 97% for only $164.90. Available - in Ligands at Aladdin Scientific. a cell permeable selective inhibitor of N-SMase (neutral sphingomyelinase) which functions as an inhibitor, via a non-competitve manner Tags: .
Basic Description
Synonyms
GW4869 also known as N-SMase Inhibitor; GW-4869; GW 4869; Sphingomyelinase; Inhibitor GW4869；4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride
Specifications & Purity
97%
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Product Description
GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). GW4869 functions as an inhibitor, via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-α in MC7 cells. As a result of this inhibition cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin.
B2301166