GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research .
1.Pease J, Horuk R. (2012) Chemokine receptor antagonists.. J Med Chem, 55 (22):(9363-92). [PMID:22931505]
2.Neighbour H, Boulet LP, Lemiere C, Sehmi R, Leigh R, Sousa AR, Martin J, Dallow N, Gilbert J, Allen A et al.. (2014) Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial.. Clin Exp Allergy, 44 (4):(508-16). [PMID:24286456]
3.Méndez-Enríquez E, Medina-Tamayo J, Soldevila G, Fortoul TI, Anton B, Flores-Romo L, García-Zepeda EA. (2014) A CCL chemokine-derived peptide (CDIP-2) exerts anti-inflammatory activity via CCR1, CCR2 and CCR3 chemokine receptors: Implications as a potential therapeutic treatment of asthma.. Int Immunopharmacol, 20 (1):(1-11). [PMID:24560857]
4.Pease JE, Horuk R. (2014) Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4.. Expert Opin Drug Discov, 9 (5):(467-83). [PMID:24641500]
6.Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O. (1996) Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.. J Biol Chem, 271 (13):(7725-30). [PMID:8631813]
7.Conroy DM, Humbles AA, Rankin SM, Palframan RT, Collins PD, Griffiths-Johnson DA, Jose PJ, Williams TJ. (1997) The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation.. Mem Inst Oswaldo Cruz, 92 Suppl 2 (3):(183-91). [PMID:9698931]
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