GW806742X hydrochloride - 98%, high purity , CAS No.G659343

Item Number

G659343

Grouped product items
SKU	Size	Availability	Price
G659343-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$60.90
G659343-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
G659343-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
G659343-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
G659343-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90

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Basic Description

Specifications & Purity	98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Product Description	GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl Appearance:Solid IC50& Target:MLKL\|9.3 μM (Kd)\|VEGFR2\|2 nM (IC\|50\|) In Vitro:GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induce Biological Activity:GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl

Canonical SMILES

[H]Cl.O=S(C1=CC=CC(NC2=NC=CC(N(C)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3)=N2)=C1)(N)=O

Molecular Weight

610.01

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Basic Description