| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| G661694-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $81.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Desiccated,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl IC50& Target:MLKL|9.3 μM (Kd)|VEGFR2|2 nM (IC|50|) In Vitro:GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induce Biological Activity:GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a K d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 ( IC 50 =2 nM). GW806742X hydrochl |
| Canonical SMILES | [H]Cl.O=S(C1=CC=CC(NC2=NC=CC(N(C)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3)=N2)=C1)(N)=O |
|---|---|
| Molecular Weight | 610.01 |
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