H-89 - 98%, high purity , CAS No.127243-85-0, Inhibitor of protein kinase; cAMP-dependent; catalytic; alpha subunit

Item Number

N302321

• Synonyms: h-89|127243-85-0|H 89|N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide|N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide|N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE|CHEMBL104264|Protein kinase inhib
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent, cell-permeable PKA inhibitor (IC 50 values are 0.14, 0.08, 0.12, 0.27, 2.6, and 2.8 µM for PKA, S6K1, MSK1, ROCK-II, PKBα, and MAPKAP-K1b respectively). Shows anti-addictive effects in vivo.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of protein kinase; cAMP-dependent; catalytic; alpha subunit
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Application：

H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.