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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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H646286-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $104.90 |
Synonyms | H-TYR-TYR-OH|Tyrosyltyrosine|Tyr-tyr|1050-28-8|L-Tyrosyl-L-tyrosine|Peptide tyrosine-tyrosine|CHEMBL95286|CHEBI:60989|(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid|(S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)Propana |
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Biochemical and Physiological Mechanisms | H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme ( ACE ) with an IC 50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure. |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Product Description | H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme ( ACE ) with an IC 50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure In Vitro H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC 50 value of 0.028 mg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo . H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Anesthetized male SpragueDawley rats Dosage: 12.5 mg/kg Administration: Intraarterial injection; 12.5 mg/kg once Result: Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration. Animal Model: Spontaneously hypertensive rats Dosage: 0, 50 and 100 mg/kg Administration: Intraperitoneal injection; once Result: Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg. Form:Solid IC50& Target:IC50: 0.028 mg/mL (ACE) |
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IUPAC Name | (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid |
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INCHI | InChI=1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1 |
InChi Key | JAQGKXUEKGKTKX-HOTGVXAUSA-N |
Canonical SMILES | C1=CC(=CC=C1CC(C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)N)O |
Isomeric SMILES | C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O)N)O |
Alternate CAS | 1050-28-8 |
PubChem CID | 70590 |
MeSH Entry Terms | L-tyrosyl-L-tyrosine;peptide tyrosine-tyrosine;Tyr-Tyr;tyrosyltyrosine |
Molecular Weight | 344.36 |
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