| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H408968-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $85.90 |
Bcl-2 Selective Inhibitors | Antagonists | Modulators
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM. |
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | Information HA14-1 is a non-peptidic ligand of aBcl-2surface pocket withIC50of ~9 μM. HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS. In vivo HA14-1(400 nM) treatment did not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice. But HA14-1 (400 nM) increases the effect of the DNA-damaging agent etoposide (2.5 mg/Kg) on glioblastoma growth in vivo. cell lines： Concentrations：~25 μM Incubation Time：20 h Powder Purity: |
| Canonical SMILES | CCOC(=O)C(C#N)C1C2=CC(=CC=C2OC(=C1C(=O)OCC)N)Br |
|---|---|
| Molecular Weight | 409.23 |
Enter Lot Number to search for COA:
| Solubility | Solubility (25°C) In vitro DMSO: 32.5 mg/mL warmed with 50ºC Water: bath (100.16 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|
