Haptoglobin, Phenotype 1-1, Human Plasma

Item Number

np001091

• Product Name: Haptoglobin, Phenotype 1-1, Human Plasma
• Specifications & Purity: ≥95%(SDS-PAGE), Extinction Coefficient: 1.20
• Predicted molecular weight: Hp1-1:86,000

Product Description

Of the three haptoglobin phenotypes, Hp 1-1 is the most effective in binding free hemoglobin and in suppressing the inflammatory responses associated with free hemoglobin. Hp 1-1 protects against vascular complications in diabetes, is associated with sickle cell anemia, and is more common than other phenotypes in cases of cirrhosis.Individuals who are phenotype 1-1 have the highest concentration of haptoglobin in plasma.

Product Citations:

Chen-Roetling J, Regan RF.Haptoglobin increases the vulnerability of CD163‐expressing neurons to hemoglobin.J Neurochem. 2016 Nov;139(4):586-595. doi: 10.1111/jnc.13720. Epub 2016 Jul 22. 

Xu S, Kaltashov IA.Evaluation of Gallium as a Tracer of Exogenous Hemoglobin-Haptoglobin Complexes for Targeted Drug Delivery Applications.J Am Soc Mass Spectrom. 2016 Dec;27(12):2025-2032. Epub 2016 Sep 12. 

Fatunmbi O, Abzalimov RR, Savinov SN, Gershenson A, Kaltashov IA.Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry.Biochemistry. 2016 Mar 29;55(12):1918-28. doi: 10.1021/acs.biochem.5b00807. Epub 2016 Mar 17.