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Home Applications Targets Kinases TK:Tyrosine kinase HDS 029 - ≥95%, high purity , CAS No.881001-19-0, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of erb-b2 receptor tyrosine kinase 4
HDS 029 - ≥95%, high purity , CAS No.881001-19-0, Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of erb-b2 receptor tyrosine kinase 4
a potent inhibitor of EGF receptor family
Basic Description Synonyms HDS 029|881001-19-0|EGFR/ErbB-2/ErbB-4 Inhibitor|HDS-029|TKI-39|ZN0X0Q76F1|TKI39|UNII-ZN0X0Q76F1|CHEMBL203644|HDS029|N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-ynamide|2-Butynamide, N-(4-((3-chloro-4-fluorophenyl)amino)pyrido(3,4-d)p Specifications & Purity Moligand™, ≥95% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of erb-b2 receptor tyrosine kinase 4 Product Description HDS 029 is a potent inhibitor of the ErbB receptor family (IC|50|values are 0.3, 0.5 and 1.1 nM for EGFR (ErbB1), ErbB-4 (ErbB4) and Neu (ErbB2) respectively). It inhibits EGF-induced EGFR (erbB1) autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC|50|values are 2.5 and 24 nM respectively).
Product Properties pKa pKₐ: 7.46 (Predicted), pKₐ: 3.59 (Predicted)
Names and Identifiers IUPAC Name N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]but-2-ynamide INCHI InChI=1S/C17H11ClFN5O/c1-2-3-16(25)24-15-7-11-14(8-20-15)21-9-22-17(11)23-10-4-5-13(19)12(18)6-10/h4-9H,1H3,(H,20,24,25)(H,21,22,23) InChi Key DLPSDPPZXRJQOY-UHFFFAOYSA-N Canonical SMILES CC#CC(=O)NC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl Isomeric SMILES CC#CC(=O)NC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl PubChem CID 11566580 Molecular Weight 355.76
Chemical and Physical Properties Solubility Soluble in DMSO (25 mM). Refractive Index n20D1.74 (Predicted)
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