Grouped product items

SKU

Size

Availability

Price

Qty

H106723-25ml

25ml

Available within 4-8 weeks(?)

$21.90

H106723-100ml

100ml

Available within 4-8 weeks(?)

$40.90

H106723-500ml

500ml

Available within 4-8 weeks(?)

$94.90

H106723-12×500ml

12×500ml

Available within 8-12 weeks(?)

$1,024.90

Basic Description

Synonyms	1,6-Diisocyanatohexane\|HEXAMETHYLENE DIISOCYANATE\|822-06-0\|1,6-Hexamethylene diisocyanate\|HMDI\|Hexane 1,6-diisocyanate\|Hexane, 1,6-diisocyanato-\|1,6-Hexylene diisocyanate\|Hexamethylene-1,6-diisocyanate\|hexamethylenediisocyanate\|1,6-Hexanediol diisocyanate
Specifications & Purity	Moligand™, ≥99%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPA1
Product Description	Hexamethylene diisocyanate is an aliphatic diisocyanate monomer typically used to produce oligomers and prepolymers that when combined with a polyol produce light-stable polyurethane.

Associated Targets

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 0 Activities

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1,6-diisocyanatohexane
INCHI	InChI=1S/C8H12N2O2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2
InChi Key	RRAMGCGOFNQTLD-UHFFFAOYSA-N
Canonical SMILES	C(CCCN=C=O)CCN=C=O
Isomeric SMILES	C(CCCN=C=O)CCN=C=O
WGK Germany	1
RTECS	MO1740000
PubChem CID	13192
UN Number	2281
Packing Group	II
Molecular Weight	168.19
Beilstein	956709
Reaxy-Rn	956709

Database links

PubChem CID	13192
CAS Registry No.	822-06-0
ChEBI	CHEBI:53578
Wikipedia	Hexamethylene diisocyanate
ChEMBL Ligand	CHEMBL1896533

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

18 results found

Lot Number	Certificate Type	Date	Item
E2421541	Certificate of Analysis	May 07, 2024	H106723
E2421128	Certificate of Analysis	May 07, 2024	H106723
E2421127	Certificate of Analysis	May 07, 2024	H106723
E2421126	Certificate of Analysis	May 07, 2024	H106723
A2426079	Certificate of Analysis	Apr 07, 2023	H106723
D23251179	Certificate of Analysis	Apr 07, 2023	H106723
D23251156	Certificate of Analysis	Apr 07, 2023	H106723
D23251011	Certificate of Analysis	Apr 07, 2023	H106723
D23251009	Certificate of Analysis	Apr 07, 2023	H106723
A2418035	Certificate of Analysis	Apr 07, 2023	H106723
K2216423	Certificate of Analysis	Nov 01, 2022	H106723
K2216424	Certificate of Analysis	Nov 01, 2022	H106723
K2216425	Certificate of Analysis	Nov 01, 2022	H106723
K2216426	Certificate of Analysis	Nov 01, 2022	H106723
H2209396	Certificate of Analysis	Jul 29, 2022	H106723
H2209406	Certificate of Analysis	Jul 29, 2022	H106723
H2209407	Certificate of Analysis	Jul 29, 2022	H106723
H2209408	Certificate of Analysis	Jul 29, 2022	H106723

Chemical and Physical Properties

Solubility	Reacts with water.Soluble in ether, benzene, toluene, acetone.
Sensitivity	Moisture sensitive, Heat sensitive
Refractive Index	1.451-1.453
Flash Point(°F)	284℉
Flash Point(°C)	140℃
Boil Point(°C)	255°C
Melt Point(°C)	-67°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS05
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H331:Toxic if inhaled H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	1
RTECS	MO1740000
Reaxy-Rn	956709
Class	6.1

Alternative Products

References

1. R Von Burg. (1993-11-01) Hexamethylene diisocyanate.. Journal of applied toxicology : JAT, 13 ((6)): (435-439). [PMID:8288848]
2. Lixin Yang,Jizheng Wei,Lesan Yan,Yubin Huang,Xiabin Jing. (2011-04-15) Synthesis of OH-group-containing, biodegradable polyurethane and protein fixation on its surface.. Biomacromolecules, 12 ((6)): (2032-2038). [PMID:21488702]
3. Sheila L Flack,Kenneth W Fent,Linda G T Gaines,Jennifer M Thomasen,Stephen G Whittaker,Louise M Ball,Leena A Nylander-French. (2011-04-22) Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 16 ((3)): (261-270). [PMID:21506697]
4. Sander M van Putten,Maike Wübben,Josée A Plantinga,Wim E Hennink,Marja J A van Luyn,Martin C Harmsen. (2011-06-18) Endotoxin contamination delays the foreign body reaction.. Journal of biomedical materials research. Part A, 98 ((4)): (527-534). [PMID:21681945]
5. Azadeh Asefnejad,Mohammad Taghi Khorasani,Aliasghar Behnamghader,Babak Farsadzadeh,Shahin Bonakdar. (2011-11-11) Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay.. International journal of nanomedicine, 6 (2375-2384). [PMID:22072874]
6. Jennifer M Thomasen,Kenneth W Fent,Leena A Nylander-French. (2011-11-15) Development of a sampling patch to measure dermal exposures to monomeric and polymeric 1,6-hexamethylene diisocyanate: a pilot study.. Journal of occupational and environmental hygiene, 8 ((12)): (709-717). [PMID:22074266]
7. Pei Wang,Lian Liu,Chao Qu,Zhiyong Wei,Min Qi. (2011-12-27) Synthesis and crystallizability of poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(ethylene glycol).. Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1 (e240-e242). [PMID:22195883]
8. Xinbo Sun,Zhengbing Cao,Nuala Porteous,Yuyu Sun. (2012-01-17) An N-halamine-based rechargeable antimicrobial and biofilm controlling polyurethane.. Acta biomaterialia, 8 ((4)): (1498-1506). [PMID:22244984]
9. Jennifer M Thomasen,Leena A Nylander-French. (2012-02-02) Penetration patterns of monomeric and polymeric 1,6-hexamethylene diisocyanate monomer in human skin.. Journal of environmental monitoring : JEM, 14 ((3)): (951-960). [PMID:22293954]
10. Victoria Arrandale,Tim Meijster,Anjoeka Pronk,Gert Doekes,Carrie A Redlich,D Linn Holness,Dick Heederik. (2012-03-14) Skin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms.. International archives of occupational and environmental health, 86 ((2)): (167-175). [PMID:22411214]
11. Berran Yucesoy,Victor J Johnson,Zana L Lummus,Grace E Kissling,Kara Fluharty,Denyse Gautrin,Jean-Luc Malo,André Cartier,Louis-Philippe Boulet,Joaquin Sastre,Santiago Quirce,Dori R Germolec,Susan M Tarlo,Maria-Jesus Cruz,Xavier Munoz,Michael I Luster,David I Bernstein. (2012-05-23) Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.. Toxicological sciences : an official journal of the Society of Toxicology, 129 ((1)): (166-173). [PMID:22610343]
12. Melisa Panos,Taner Z Sen,M Göktuğ Ahunbay. (2012-08-04) Molecular simulation of fibronectin adsorption onto polyurethane surfaces.. Langmuir : the ACS journal of surfaces and colloids, 28 ((34)): (12619-12628). [PMID:22856639]
13. Melissa A Fierke,Eric J Olson,Philippe Bühlmann,Andreas Stein. (2012-08-22) Receptor-based detection of 2,4-dinitrotoluene using modified three-dimensionally ordered macroporous carbon electrodes.. ACS applied materials & interfaces, 4 ((9)): (4731-4739). [PMID:22905948]
14. Zibiao Li,Zhongxing Zhang,Kerh Li Liu,Xiping Ni,Jun Li. (2012-11-22) Biodegradable hyperbranched amphiphilic polyurethane multiblock copolymers consisting of poly(propylene glycol), poly(ethylene glycol), and polycaprolactone as in situ thermogels.. Biomacromolecules, 13 ((12)): (3977-3989). [PMID:23167676]
15. Anning Wang,Hui Gao,Yanfang Sun,Yu-long Sun,Ying-Wei Yang,Guolin Wu,Yinong Wang,Yunge Fan,Jianbiao Ma. (2012-12-25) Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery.. International journal of pharmaceutics, 441 ((1-2)): (30-39). [PMID:23262421]
16. Zhu Xiong,Lisheng Zhang,Songqi Ma,Yong Yang,Chuanzhi Zhang,Zhaobin Tang,Jin Zhu. (2013-04-03) Effect of castor oil enrichment layer produced by reaction on the properties of PLA/HDI-g-starch blends.. Carbohydrate polymers, 94 ((1)): (235-243). [PMID:23544534]
17. M A Hughes,M Carson,M A Collins,A T Jolly,D M Molenaar,W Steffens,G M H Swaen. (2014-03-22) Does diisocyanate exposure result in neurotoxicity?. Clinical toxicology (Philadelphia, Pa.), 52 ((4)): (242-257). [PMID:24645904]
18. Badri Sadat Jonaid,Anjoeka Pronk,Gert Doekes,Dick Heederik. (2014-04-01) Exhaled nitric oxide in spray painters exposed to isocyanates: effect modification by atopy and smoking.. Occupational and environmental medicine, 71 ((6)): (415-422). [PMID:24683011]
19. Ying Yang,Marek W Urban. (2014-09-16) Self-repairable polyurethane networks by atmospheric carbon dioxide and water.. Angewandte Chemie (International ed. in English), 53 ((45)): (12142-12147). [PMID:25220903]
20. Elia M Schneider,Renzo A Raso,Corinne J Hofer,Martin Zeltner,Robert D Stettler,Samuel C Hess,Robert N Grass,Wendelin J Stark. (2014-10-18) Magnetic superbasic proton sponges are readily removed and permit direct product isolation.. The Journal of organic chemistry, 79 ((22)): (10908-10915). [PMID:25325822]
21. Simon C Baker,Geraldine Rohman,Jennifer Hinley,Jens Stahlschmidt,Neil R Cameron,Jennifer Southgate. (2011-02-24) Cellular integration and vascularisation promoted by a resorbable, particulate-leached, cross-linked poly(ε-caprolactone) scaffold.. Macromolecular bioscience, 11 ((5)): (618-627). [PMID:21344647]
22. Jennifer M Thomasen,Kenneth W Fent,Carolyn Reeb-Whitaker,Stephen G Whittaker,Leena A Nylander-French. (2011-02-25) Field comparison of air sampling methods for monomeric and polymeric 1,6-hexamethylene diisocyanate.. Journal of occupational and environmental hygiene, 8 ((3)): (161-178). [PMID:21347958]
23. Wenxing Gu,Yanan Ma,Chuyu Zhu,Baoquan Chen,Jianbiao Ma,Hui Gao. (2012-08-14) Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47 ((3)): (556-563). [PMID:22884627]
24. Jeffry D Schroeter,Julia S Kimbell,Bahman Asgharian,Earl W Tewksbury,Mark Sochaski,Melanie L Foster,David C Dorman,Brian A Wong,Melvin E Andersen. (2013-02-21) Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts.. Inhalation toxicology, 25 ((3)): (168-177). [PMID:23421488]
25. Ying-Yu Chen,Hsi-Chin Wu,Jui-Sheng Sun,Guo-Chung Dong,Tzu-Wei Wang. (2013-02-28) Injectable and thermoresponsive self-assembled nanocomposite hydrogel for long-term anticancer drug delivery.. Langmuir : the ACS journal of surfaces and colloids, 29 ((11)): (3721-3729). [PMID:23441993]
26. ZhouXue Wu,XiaoYan Zou,LingLin Yang,Sheng Lin,Juan Fan,Bo Yang,XiaoYang Sun,Qiang Wan,Yue Chen,ShaoZhi Fu. (2014-07-18) Thermosensitive hydrogel used in dual drug delivery system with paclitaxel-loaded micelles for in situ treatment of lung cancer.. Colloids and surfaces. B, Biointerfaces, 122 (90-98). [PMID:25033428]
27. Leena A Nylander-French,Michael C Wu,John E French,Jayne C Boyer,Lisa Smeester,Alison P Sanders,Rebecca C Fry. (2014-12-03) DNA methylation modifies urine biomarker levels in 1,6-hexamethylene diisocyanate exposed workers: a pilot study.. Toxicology letters, 231 ((2)): (217-226). [PMID:25445006]

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Hexamethylene diisocyanate - 99%, high purity , CAS No.822-06-0, Activator of TRPA1

Basic Description

Associated Targets

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

THRB Tclin Thyroid hormone receptor beta 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
H106723-25ml	25ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$21.90
H106723-100ml	100ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$40.90
H106723-500ml	500ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$94.90
H106723-12×500ml	12×500ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,024.90