Hh-Ag1.5 , CAS No.612542-14-0

Item Number

H649711

Grouped product items
SKU	Size	Availability	Price
H649711-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
H649711-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90
H649711-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90

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Basic Description

Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Hh-Ag1.5 (SAg1.5) is a potent Hedgehog ( Hh ) agonist with an EC 50 of 1 nM Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure . In Vitro HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133 + CD45 - liver stem cells (Hh3A cells) enriched from non-injured liver in vitro. Hh-Ag1.5 competely binds to the Smo-containing membranes with the K i value of 0.52 nM. The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC 50 of 7 nM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 1 nM (Hedgehog)

Names and Identifiers

IUPAC Name	3-chloro-4,7-difluoro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide
INCHI	InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4,9-15,20-21,32H,5-8,16H2,1H3
InChi Key	RXZDWPYJFCAZCW-UHFFFAOYSA-N
Canonical SMILES	CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=C(C=CC(=C5S4)F)F)Cl
Isomeric SMILES	CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=C(C=CC(=C5S4)F)F)Cl
PubChem CID	44195701
Molecular Weight	526.04

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Basic Description