Basic Description

Synonyms	Histidine Leucine dipeptide \| PARA-TOLYL-3-METHYL BUTYRATE \| H-HIS-LEU-OH \| HL dipeptide \| H-L Dipeptide \| L-Leucine,l-histidyl- \| L-Leucine, L-histidyl- \| N-L-Histidyl-L-leucine \| Q27106873 \| BDBM50005257 \| BDBM50407435 \| N-L-Histidyl-L-leucin \| MMFKFJOR
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (0 Activities)

Discover Target: ACE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid
INCHI	InChI=1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)/t9-,10-/m0/s1
InChi Key	MMFKFJORZBJVNF-UWVGGRQHSA-N
Canonical SMILES	CC(C)CC(C(=O)O)NC(=O)C(CC1=CN=CN1)N
Isomeric SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)N
WGK Germany	3
Alternate CAS	7763-65-7
PubChem CID	189008
MeSH Entry Terms	His-Leu;histidylleucine
Molecular Weight	268.31

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

WGK Germany	3

References

1. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. (2001) Cloning of a lymphatic peptide/histidine transporter.. Biochem J, 356 (Pt 1): (53-60). [PMID:11336635]
2. H Iwata,K Saito,S Furusaki,T Sugo,J Okamoto. (1991-09-01) Adsorption characteristics of an immobilized metal affinity membrane.. Biotechnology progress, 7 ((5)): (412-418). [PMID:1367992]
3. V Schusdziarra,R Schmid,H Bender,M Schusdziarra,J Rivier,W Vale,M Classen. (1986-01-01) Effect of vasoactive intestinal peptide, peptide histidine isoleucine and growth hormone-releasing factor-40 on bombesin-like immunoreactivity, somatostatin and gastrin release from the perfused rat stomach.. Peptides, 7 ((1)): (127-133). [PMID:2872659]
4. R A Santos,E M Krieger,L J Greene. (1985-03-01) An improved fluorometric assay of rat serum and plasma converting enzyme.. Hypertension (Dallas, Tex. : 1979), 7 ((2)): (244-252). [PMID:2984118]
5. J B Vita,J A Anderson,C D Hulem,I H Leopold. (1981-02-01) Angiotensin-converting enzyme activity in ocular fluids.. Investigative ophthalmology & visual science, 20 ((2)): (255-257). [PMID:6257623]
6. R Baranowski,C Westenfelder,B L Currie. (1982-03-15) Identification of enzymatically produced peptide fragments by liquid chromatography and mass spectrometry.. Analytical biochemistry, 121 ((1)): (97-102). [PMID:6283944]
7. K Iwatsuki,L M Ren,S Chiba. (1993-07-01) Effects of peptide histidine isoleucine on pancreatic exocrine secretion in anaesthetized dogs.. Clinical and experimental pharmacology & physiology, 20 ((7-8)): (501-507). [PMID:8403531]
8. Pulimamidi R Reddy,Kandibanda S Rao,Sepuru K Mohan. (2006-12-29) Copper(II) complexes containing N,N-donor ligands and dipeptides act as hydrolytic DNA-cleavage agents.. Chemistry & biodiversity, 1 ((6)): (839-853). [PMID:17191884]
9. Pulimamidi R Reddy,Sepuru K Mohan,Kandibanda S Rao. (2006-12-29) Ternary zinc(II)-dipeptide complexes for the hydrolytic cleavage of DNA at physiological pH.. Chemistry & biodiversity, 2 ((5)): (672-683). [PMID:17192010]
10. Carl Henrik Görbitz. (2010-11-06) L-histidyl-L-serine 3.7-hydrate: water channels in the crystal structure of a polar dipeptide.. Acta crystallographica. Section C, Crystal structure communications, 66 ((Pt 11)): (o531-o534). [PMID:21051819]
11. Rogerio Faustino Ribeiro,Felipe F Potratz,Brunella M M Pavan,Ludimila Forechi,Filipe Lugon Moulin Lima,Jonaina Fiorim,Aurelia Araujo Fernandes,Dalton Valentim Vassallo,Ivanita Stefanon. (2013-01-12) Carvedilol prevents ovariectomy-induced myocardial contractile dysfunction in female rat.. PloS one, 8 ((1)): (e53226-e53226). [PMID:23308166]
12. Eun Hui Bae,Ana Konvalinka,Fei Fang,Xiaohua Zhou,Vanessa Williams,Nicholas Maksimowski,Xuewen Song,Shao-Ling Zhang,Rohan John,Gavin Y Oudit,York Pei,James W Scholey. (2015-03-18) Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome.. The American journal of pathology, 185 ((5)): (1423-1435). [PMID:25777062]
13. Alice B Nongonierma,Mehdeeyah Lalmahomed,Sara Paolella,Richard J FitzGerald. (2017-04-30) Milk protein isolate (MPI) as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides.. Food chemistry, 231 (202-211). [PMID:28449998]
14. Yu Cao,Shaoyang Hu,Tingting Gong,Qiming Xian,Bin Xu. (2019-05-22) Decomposition of β-N-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) during chlorination and consequent\xa0disinfection byproducts formation.. Water research, 159 (365-374). [PMID:31112889]
15. A P O Leite,Danielle S Aragão,Marie D Nogueira,Renata O Pereira,Zaira P Jara,Patricia Fiorino,Dulce E Casarini,Vera Farah. (2019-05-28) Modulation of renin\xa0angiotensin system components by high glucose levels in the culture of collecting duct cells.. Journal of cellular physiology, 234 ((12)): (22809-22818). [PMID:31131896]
16. A C Shisheva,T Dimitrov,O C Ikonomov. (1991-01-01) Plasma angiotensin-converting enzyme activity and blood pressure during the first year of life in normotensive and spontaneously hypertensive rat.. Acta physiologica Hungarica, 77 ((2)): (129-138). [PMID:1656699]
17. S Ceccatelli,M Eriksson,T Hökfelt. (1989-03-01) Distribution and coexistence of corticotropin-releasing factor-, neurotensin-, enkephalin-, cholecystokinin-, galanin- and vasoactive intestinal polypeptide/peptide histidine isoleucine-like peptides in the parvocellular part of the paraventricular nucleus.. Neuroendocrinology, 49 ((3)): (309-323). [PMID:2469987]
18. R Reneland,H Lithell. (1994-04-01) Angiotensin-converting enzyme in human skeletal muscle. A simple in vitro assay of activity in needle biopsy specimens.. Scandinavian journal of clinical and laboratory investigation, 54 ((2)): (105-111). [PMID:8197396]
19. J A Krause,P W Baures,D S Eggleston. (1993-02-01) Molecular structures of L-Leu-L-Tyr, Gly-D,L-Met.p-toluenesulfonate and L-His-L-Leu.. Acta crystallographica. Section B, Structural science, 49 ( Pt 1) (123-130). [PMID:8442925]
20. Pulimamidi R Reddy,Pallerla Manjula,Sepuru K Mohan. (2006-12-29) Novel peptide-based copper(II) complexes for total hydrolytic cleavage of DNA.. Chemistry & biodiversity, 2 ((10)): (1338-1350). [PMID:17191935]
21. Pulimamidi R Reddy,Kandibanda S Rao. (2006-12-29) Ternary nickel(II) complexes as hydrolytic DNA-cleavage agents.. Chemistry & biodiversity, 3 ((2)): (231-244). [PMID:17193262]
22. Michaela Knapp-Mohammady,Alex B Young,Béla Paizs,Alex G Harrison. (2009-08-18) Fragmentation of doubly-protonated Pro-His-Xaa tripeptides: formation of b(2)(2+) ions.. Journal of the American Society for Mass Spectrometry, 20 ((11)): (2135-2143). [PMID:19683937]
23. Thangarasu Silambarasan,Jeganathan Manivannan,Mani Krishna Priya,Natarajan Suganya,Suvro Chatterjee,Boobalan Raja. (2014-12-23) Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats.. PloS one, 9 ((12)): (e115682-e115682). [PMID:25531679]

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SKU	Size	Availability	Price
H121429-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$153.90
H121429-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$510.90
H121429-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,299.90

His-Leu - 97%, high purity , CAS No.7763-65-7