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HLCL-61 HCL - 98% , high purity , CAS No.1158279-20-9

≥98%

CAS#: 1158279-20-9
Formula: C₂₃H₂₄N₂O.HCl
Molecular Weight: 380.91
PubChem CID: 17208222

Item Number

H413945

Grouped product items
SKU	Size	Availability	Price
H413945-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
H413945-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$147.90
H413945-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90

PRMT Inhibitors

Basic Description

Synonyms	HLCL619H-Carbazole-3-methanamine,9-ethyl-N-[(2-methoxyphenyl)methyl]-,hydrochloride (1:1);1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information HLCL-61 HCL HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. Targets PRMT5 (In THP-1 cells) 16.74 μM In vitro HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h. Cell Research(from reference) Cell lines：AML cell lines Concentrations：25,50uM Incubation Time：48h

ALogP

5.364

HBD Count

Rotatable Bond

Names and Identifiers

IUPAC Name	1-(9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine;hydrochloride
INCHI	InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
InChi Key	XYAVCNMZZKTEGR-UHFFFAOYSA-N
Canonical SMILES	CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
Isomeric SMILES	CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
PubChem CID	17208222
Molecular Weight	380.91

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
J2214478	Certificate of Analysis	Jun 20, 2022	H413945
J2214489	Certificate of Analysis	Jun 20, 2022	H413945
J2214507	Certificate of Analysis	Jun 20, 2022	H413945

Solubility

Solubility (25°C) In vitro DMSO: 76 mg/mL (199.52 mM); Ethanol: 76 mg/mL (199.52 mM); Water: Insoluble;

Sensitivity

Moisture sensitive

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

199.5221968

Water(mg / mL) Max Solubility

＜1

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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HLCL-61 HCL - 98% , high purity , CAS No.1158279-20-9

Basic Description

Product Properties