| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H420735-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $197.90 |
PRMT Inhibitors
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information HLCL-61 HCL HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. Targets PRMT5 (In THP-1 cells) 16.74 μM In vitro HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h. Cell Research(from reference) Cell lines：AML cell lines Concentrations：25,50uM Incubation Time：48h |
| ALogP | 5.364 |
|---|---|
| HBD Count | 1 |
| Rotatable Bond | 6 |
| IUPAC Name | 1-(9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine;hydrochloride |
|---|---|
| INCHI | InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H |
| InChi Key | XYAVCNMZZKTEGR-UHFFFAOYSA-N |
| Canonical SMILES | CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl |
| Isomeric SMILES | CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl |
| PubChem CID | 17208222 |
| Molecular Weight | 380.91 |
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| DMSO(mg / mL) Max Solubility | 76 |
|---|---|
| DMSO(mM) Max Solubility | 199.5221968 |
| Water(mg / mL) Max Solubility | ＜1 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
