| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H341159-10mg | 10mg | In stock | $238.90 | |
| H341159-50mg | 50mg | In stock | $1,073.90 |
a bupropion metabolite
| Synonyms | FT-0669438 | 2-(3-CHLOROPHENYL)-3,5,5-TRIMETHYLMORPHOLIN-2-OL | Hydroxy Bupropion | AS-6162 | 2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol | Bupropion morpholinol | BUPROPIONMORPHOLINOL | Oprea1_654095 | AKOS025149627 | FT-0669436 | SCHEMBL2599138 | D |
|---|---|
| Specifications & Purity | ≥98% |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Hydroxy Bupropion is a major metabolite of the dopamine transport inhibitor and nicotinic antagonist bupropion . Hydroxy bupropion is formed by hydroxylation of bupropion on the tert-butyl group and cyclizes to an acetal. This is a racemic preparation of the R,R-hydroxy bupropion and S,S-hydroxy bupropion isomers. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol |
|---|---|
| INCHI | InChI=1S/C13H18ClNO2/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3 |
| InChi Key | RCOBKSKAZMVBHT-UHFFFAOYSA-N |
| Canonical SMILES | CC1C(OCC(N1)(C)C)(C2=CC(=CC=C2)Cl)O |
| Isomeric SMILES | CC1C(OCC(N1)(C)C)(C2=CC(=CC=C2)Cl)O |
| PubChem CID | 9837966 |
| Molecular Weight | 255.74 |
Enter Lot Number to search for COA:
| Solubility | Soluble in Acetone, Acetonitrile and Ethyl Acetate |
|---|
| 1. Zifei Qin, Peile Wang, Shuyi Duan, Xiaoying Wan, Han Xing, Jing Yang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao. (2021) Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters. JOURNAL OF PHARMACEUTICAL SCIENCES, 110 (2285). [PMID:33610566] [10.1016/j.xphs.2021.02.013] |
| 2. Xinqiang Li, Han Xing, Zifei Qin, Jing Yang, Peile Wang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao. (2020) Potential metabolism determinants and drug–drug interactions of a natural flavanone bavachinin. RSC Advances, 10 (58): (35141-35152). [PMID:35515695] [10.1039/D0RA06961B] |
| 3. Xing Han, Yang Jing, Ren Kaidi, Qin Zifei, Wang Peile, Zhang Xiaojian, Yao Zhihong, Gonzalez Frank J, Yao Xinsheng. (2020) Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1865-1878). [PMID:32750744] [10.1111/jphp.13337] |
| 4. Qin Zifei, Jia Mengmeng, Yang Jing, Xing Han, Yin Zhao, Yao Zhihong, Zhang Xiaojian, Yao Xinsheng. (2020) Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions. Chinese Medicine, 15 (1): (1-18). [PMID:32655683] [10.1186/s13020-020-00349-3] |
| 1. Zifei Qin, Peile Wang, Shuyi Duan, Xiaoying Wan, Han Xing, Jing Yang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao. (2021) Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters. JOURNAL OF PHARMACEUTICAL SCIENCES, 110 (2285). [PMID:33610566] [10.1016/j.xphs.2021.02.013] |
| 2. Xinqiang Li, Han Xing, Zifei Qin, Jing Yang, Peile Wang, Xiaojian Zhang, Zhihong Yao, Xinsheng Yao. (2020) Potential metabolism determinants and drug–drug interactions of a natural flavanone bavachinin. RSC Advances, 10 (58): (35141-35152). [PMID:35515695] [10.1039/D0RA06961B] |
| 3. Xing Han, Yang Jing, Ren Kaidi, Qin Zifei, Wang Peile, Zhang Xiaojian, Yao Zhihong, Gonzalez Frank J, Yao Xinsheng. (2020) Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (12): (1865-1878). [PMID:32750744] [10.1111/jphp.13337] |
| 4. Qin Zifei, Jia Mengmeng, Yang Jing, Xing Han, Yin Zhao, Yao Zhihong, Zhang Xiaojian, Yao Xinsheng. (2020) Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions. Chinese Medicine, 15 (1): (1-18). [PMID:32655683] [10.1186/s13020-020-00349-3] |
B2419165