| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H341277-1mg | 1mg | In stock | $285.90 | |
| H341277-5mg | 5mg | In stock | $1,282.90 |
a thio analog of Sildenafil and a potential PDE5 inhibitor.
| Synonyms | Hydroxythiohomo Sildenafil-protocol with the exact weight | 4-[[3-(4,7-Dihydro-1-methyl-3-propyl-7-thioxo-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol; | Hydroxyhomosildenafil thione | AKOS030242133 | Q27266620 | HYDROXYH |
|---|---|
| Specifications & Purity | ≥95% |
| Storage Temp | Store at -20°C,Argon charged |
| Shipped In | Ice chest + Ice pads |
| Product Description | Hydroxythiohomo Sildenafil is a thio analog of Sildenafil which has been reported to be a PDE5 inhibitor. Sildenafil is a selective inhibitor of type 5 cGMP phosphodiesterase (PDE5), which catalyzes teh hydrolysis of cGMP, an important secondary messenger molecule in a variety of cellular processes. Sildenafil has been reported to enhance angiogenesis in rat models of stroke and also has been reported to be a mild vasodilator. Sildenafil has been shown to prevent indomethacin-induced small intestinal ulceration formation throuh an NO/cGMP-dependent mechanism. |
| IUPAC Name | 5-[2-ethoxy-5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidine-7-thione |
|---|---|
| INCHI | InChI=1S/C23H32N6O4S2/c1-4-6-18-20-21(27(3)26-18)23(34)25-22(24-20)17-15-16(7-8-19(17)33-5-2)35(31,32)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,34) |
| InChi Key | XZVSAQIQEGFWQS-UHFFFAOYSA-N |
| Canonical SMILES | CCCC1=NN(C2=C1NC(=NC2=S)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCO)OCC)C |
| Isomeric SMILES | CCCC1=NN(C2=C1NC(=NC2=S)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCO)OCC)C |
| PubChem CID | 9936526 |
| Molecular Weight | 520.67 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2322651 | Certificate of Analysis | Jul 07, 2023 | H341277 |
| G2322652 | Certificate of Analysis | Jul 07, 2023 | H341277 |
| G2322655 | Certificate of Analysis | Jul 07, 2023 | H341277 |
| G2322662 | Certificate of Analysis | Jul 07, 2023 | H341277 |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
|---|---|
| Melt Point(°C) | 174-177° C (lit.) |
