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Hypericin - 96%, high purity , CAS No.548-04-9

Item Number
H110188
Grouped product items
SKUSizeAvailabilityPrice Qty
H110188-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
H110188-25mg
25mg
In stock
$359.90
H110188-50mg
50mg
In stock
$539.90
H110188-100mg
100mg
In stock
$739.90

Selective PKC inhibitor. Antiviral agent.

Basic Description

SynonymsCCG-36081 | 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione | 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone | hypericin | DTXSID40203270 | Hypericin & Visible light | LMPK13040001 | NCI60_006799 | M01850 | MFCD0001668
Specifications & PurityMoligand™, ≥96%
Biochemical and Physiological MechanismsSelective PKC inhibitor (IC 50 = 3.3 μM). Antiviral agent. Potent tyrosine kinase inhibitor (IC 50 = 7.5 μM). Potent CKII inhibitor (IC 50 = 6 nM). Inactivates enveloped viruses including HIV. Promotes VEGF and TGF-β production.
Storage TempStore at 2-8°C,Protected from light
Shipped InWet ice
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name 9,11,13,16,18,20-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(26),2,4(25),5,8,10,12,14(28),15(27),16,18,20,23-tridecaene-7,22-dione
INCHI InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,33-38H,1-2H3
InChi Key YDOIFHVUBCIUHF-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O
Isomeric SMILES CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O
WGK Germany 3
Alternate CAS 1372719-41-9,548-04-9
PubChem CID 3663
NSC Number 407313
MeSH Entry Terms 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione;hipericin;hypericin;hypericum red;mono-(123I)iodohypericin;SGX-301;SGX301
Molecular Weight 504.44
Beilstein 1917913

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
H2427432Certificate of AnalysisSep 03, 2024 H110188
H2427439Certificate of AnalysisSep 03, 2024 H110188
A2402115Certificate of AnalysisJul 20, 2022 H110188
G2215445Certificate of AnalysisJul 20, 2022 H110188
G2215446Certificate of AnalysisJul 20, 2022 H110188
G2215447Certificate of AnalysisJul 20, 2022 H110188

Chemical and Physical Properties

SensitivityLight sensitive.

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3

Related Documents

Citations of This Product(1)

1. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng.  (2014)  Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs.  FOOD CHEMISTRY,  164  (74).  [PMID:24996308] [10.1016/j.foodchem.2014.05.004]

References

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60. Diana Búzová,Peter Kasák,Pavol Miškovský,Daniel Jancura.  (2013-03-13)  Solubilization of poorly soluble photosensitizer hypericin by polymeric micelles and polyethylene glycol..  General physiology and biophysics,  32  ((2)): (201-208).  [PMID:23479449]
61. Emilio Russo,Francesca Scicchitano,Benjamin J Whalley,Carmela Mazzitello,Miriam Ciriaco,Stefania Esposito,Marinella Patanè,Roy Upton,Michela Pugliese,Serafina Chimirri,Maria Mammì,Caterina Palleria,Giovambattista De Sarro.  (2013-07-31)  Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions..  Phytotherapy research : PTR,  28  ((5)): (643-655).  [PMID:23897801]
62. Binghu Jiang,Jichen Wang,Yicheng Ni,Feng Chen.  (2013-09-21)  Necrosis avidity: a newly discovered feature of hypericin and its preclinical applications in necrosis imaging..  Theranostics,  ((9)): (667-676).  [PMID:24052807]
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