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I-432 , CAS No.I610896, Inhibitor of ST14 transmembrane serine protease matriptase;Inhibitor of transmembrane serine protease 2

Moligand™

PubChem CID: 146025595

Item Number

I610896

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SKU	Size	Availability	Price	Qty
I610896-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I610896-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$6,003.90

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ST14 transmembrane serine protease matriptase Inhibitor transmembrane serine protease 2 Inhibitor

Synonyms

I432

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of ST14 transmembrane serine protease matriptase;Inhibitor of transmembrane serine protease 2

Associated Targets

ST14 Tchem Suppressor of tumorigenicity 14 protein 0 Activities

Discover Target: ST14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TMPRSS2 Tchem Transmembrane protease serine 2 0 Activities

Discover Target: TMPRSS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[(2R)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-[3-(4,6-dichlorocyclohexa-1,5-dien-1-yl)benzenesulfonamido]-3-oxopropyl]benzene-1-carboximidamide
INCHI	InChI=1S/C29H35Cl2N5O3S/c30-23-7-8-25(26(31)18-23)21-4-2-6-24(17-21)40(38,39)35-27(16-20-3-1-5-22(15-20)28(33)34)29(37)36-13-10-19(9-12-32)11-14-36/h1-6,8,15,17-19,23,27,35H,7,9-14,16,32H2,(H3,33,34)/t23?,27-/m1/s1
InChi Key	LMPUOHRYPACLDR-IQHZPMLTSA-N
Canonical SMILES	NCCC1CCN(CC1)C(=O)[C@H](NS(=O)(=O)c1cccc(c1)C1=CCC(C=C1Cl)Cl)Cc1cccc(c1)C(=N)N
PubChem CID	146025595

Reactome Reaction

R-HSA-9681514

Reactome Drug

R-ALL-9682036

PubChem CID

146025595

References

1. Esumi M, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, Sugitani M, Takayama T, Tahara M, Takeda M et al.. (2015) Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.. Hepatology, 61 (2): (437-46). [PMID:25203900]
2. Pászti-Gere E, Czimmermann E, Ujhelyi G, Balla P, Maiwald A, Steinmetzer T. (2016) In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.. J Enzyme Inhib Med Chem, 31 (sup2): (123-129). [PMID:27277342]

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I-432 , CAS No.I610896, Inhibitor of ST14 transmembrane serine protease matriptase;Inhibitor of transmembrane serine protease 2

Basic Description

Associated Targets

ST14 Tchem Suppressor of tumorigenicity 14 protein 0 Activities

TMPRSS2 Tchem Transmembrane protease serine 2 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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Dilution Calculator

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