Grouped product items

SKU

Size

Availability

Price

Qty

I166771-5mg

5mg

In stock

$103.90

I166771-10mg

10mg

In stock

$153.90

I166771-25mg

25mg

In stock

$346.90

I166771-50mg

50mg

In stock

$450.90

I166771-100mg

100mg

In stock

$741.90

I166771-250mg

250mg

In stock

$1,669.90

Basic Description

Synonyms	1260907-17-2\|molibresib\|I-BET-762\|GSK 525762A\|GSK525762A\|I-BET 762\|GSK525762\|GSK-525762\|I-BET762\|Bet inhibitor GSK525762\|GSK-525762A\|UNII-5QIO6SRZ2R\|5QIO6SRZ2R\|(S)-2-(6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-y
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and high affinity BRD inhibitor (IC50= 32.5 - 42.5 nM; Kd= 50.5 - 61.3 nM). Inhibits myeloma cell proliferation. Attenuates transcription of oncogenic MYC and suppresses key inflammatory genes. Exhibits efficacy in a range of oncology and immunoinf
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Bromodomain and extra-terminal motif (BET) inhibitor

Product Properties

ALogP	2.9

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EP300 Tchem Histone acetyltransferase p300 0 Activities

Discover Target: EP300

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CREBBP Tchem CREB-binding protein 0 Activities

Discover Target: CREBBP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 58 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMARCA4 Tchem Transcription activator BRG1 0 Activities

Discover Target: SMARCA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK7 Tchem Mitogen-activated protein kinase 7 0 Activities

Discover Target: MAPK7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRDT Tchem Bromodomain testis-specific protein 2 Activities

Discover Target: BRDT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD3 Tchem Bromodomain-containing protein 3 16 Activities

Discover Target: BRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD2 Tchem Bromodomain-containing protein 2 18 Activities

Discover Target: BRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATAD2 Tchem ATPase family AAA domain-containing protein 2 0 Activities

Discover Target: ATAD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488201413
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201413
IUPAC Name	2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
INCHI	InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
InChi Key	AAAQFGUYHFJNHI-SFHVURJKSA-N
Canonical SMILES	CCNC(=O)CC1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C
Isomeric SMILES	CCNC(=O)C[C@H]1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C
PubChem CID	46943432
Molecular Weight	423.9

Database links

PubChem CID	46943432
CAS Registry No.	1260907-17-2
ChEMBL Ligand	CHEMBL1232461
RCSB PDB Ligand	EAM
PubChem SID	488201413

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
D2317135	Certificate of Analysis	Mar 09, 2023	I166771
D2317136	Certificate of Analysis	Mar 09, 2023	I166771
D2317139	Certificate of Analysis	Mar 09, 2023	I166771
D2317141	Certificate of Analysis	Mar 09, 2023	I166771
D2317142	Certificate of Analysis	Mar 09, 2023	I166771
D2317148	Certificate of Analysis	Mar 09, 2023	I166771
D2317149	Certificate of Analysis	Mar 09, 2023	I166771
D2317151	Certificate of Analysis	Mar 09, 2023	I166771
D2317152	Certificate of Analysis	Mar 09, 2023	I166771
D2317153	Certificate of Analysis	Mar 09, 2023	I166771
D2317162	Certificate of Analysis	Mar 09, 2023	I166771
D2317228	Certificate of Analysis	Mar 09, 2023	I166771

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 42.39, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 42.39, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS05
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H373:Causes damage to organs through prolonged or repeated exposure H314:Causes severe skin burns and eye damage H318:Causes serious eye damage H360:May damage fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.

References

1. Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H et al.. (2010) Suppression of inflammation by a synthetic histone mimic.. Nature, 468 (7327): (1119-23). [PMID:21068722]
2. Chung CW, Coste H, White JH, Mirguet O, Wilde J, Gosmini RL, Delves C, Magny SM, Woodward R, Hughes SA et al.. (2011) Discovery and characterization of small molecule inhibitors of the BET family bromodomains.. J Med Chem, 54 (11): (3827-38). [PMID:21568322]
3. Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry MS, Rotolo A, Tough DF, Smithers NN, Bassil AK et al.. (2014) Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.. Blood, 123 (5): (697-705). [PMID:24335499]
4. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.. Biochim Biophys Acta, 1812 (8): (982-94). [PMID:21193033]

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I-BET762 - 98% (HPLC), high purity , Bromodomain and extra-terminal motif (BET) inhibitor, CAS No.1260907-17-2, Bromodomain and extra-terminal motif (BET) inhibitor

Basic Description

Product Properties

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

EP300 Tchem Histone acetyltransferase p300 0 Activities

CREBBP Tchem CREB-binding protein 0 Activities

BRD4 Tchem Bromodomain-containing protein 4 58 Activities

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

SMARCA4 Tchem Transcription activator BRG1 0 Activities

MAPK7 Tchem Mitogen-activated protein kinase 7 0 Activities

BRDT Tchem Bromodomain testis-specific protein 2 Activities

BRD3 Tchem Bromodomain-containing protein 3 16 Activities

BRD2 Tchem Bromodomain-containing protein 2 18 Activities

ATAD2 Tchem ATPase family AAA domain-containing protein 2 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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