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I-C11 , CAS No.I610912, Inhibitor of protein tyrosine phosphatase non-receptor type 1;Inhibitor of protein tyrosine phosphatase non-receptor type 22

Moligand™

PubChem CID: 25262525

Item Number

I610912

Grouped product items
SKU	Size	Availability	Price	Qty
I610912-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I610912-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

protein tyrosine phosphatase non-receptor type 1 Inhibitor protein tyrosine phosphatase non-receptor type 22 Inhibitor

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of protein tyrosine phosphatase non-receptor type 1;Inhibitor of protein tyrosine phosphatase non-receptor type 22

Associated Targets

DUSP3 Tchem Dual specificity protein phosphatase 3 0 Activities

Discover Target: DUSP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 0 Activities

Discover Target: PTPN11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN7 Tchem Tyrosine-protein phosphatase non-receptor type 7 0 Activities

Discover Target: PTPN7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPRF Tchem Receptor-type tyrosine-protein phosphatase F 0 Activities

Discover Target: PTPRF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN9 Tchem Tyrosine-protein phosphatase non-receptor type 9 0 Activities

Discover Target: PTPN9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN13 Tchem Tyrosine-protein phosphatase non-receptor type 13 0 Activities

Discover Target: PTPN13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 0 Activities

Discover Target: PTPN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPRA Tchem Receptor-type tyrosine-protein phosphatase alpha 0 Activities

Discover Target: PTPRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN22 Tchem Tyrosine-protein phosphatase non-receptor type 22 0 Activities

Discover Target: PTPN22

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPRC Tchem Receptor-type tyrosine-protein phosphatase C 0 Activities

Discover Target: PTPRC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid
INCHI	InChI=1S/C31H24N4O5/c36-26-17-27-23(16-22(26)31(38)39)29(30(40-27)20-9-2-1-3-10-20)25-18-35(34-33-25)15-7-14-28(37)32-24-13-6-11-19-8-4-5-12-21(19)24/h1-6,8-13,16-18,36H,7,14-15H2,(H,32,37)(H,38,39)
InChi Key	RSPKMGDZBNPGGF-UHFFFAOYSA-N
Canonical SMILES	O=C(Nc1cccc2c1cccc2)CCCn1nnc(c1)c1c(oc2c1cc(C(=O)O)c(c2)O)c1ccccc1
Isomeric SMILES	C1=CC=C(C=C1)C2=C(C3=CC(=C(C=C3O2)O)C(=O)O)C4=CN(N=N4)CCCC(=O)NC5=CC=CC6=CC=CC=C65
PubChem CID	25262525

PubChem CID

25262525

ChEMBL Ligand

CHEMBL260920

BindingDB Ligand

50335895

References

1. Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.. Proc Natl Acad Sci USA, 104 (50): (19767-72). [PMID:18056643]
2. Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y et al.. (2011) Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.. J Med Chem, 54 (6): (1640-54). [PMID:21341673]

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