| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| I655703-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $374.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Desiccated,Store at -80°C |
| Shipped In | Dry ice |
| Product Description | IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1 , with an IC 50 of 8 nM for TRIM24, and K d s of 31 nM and 14 nM for TRIM24 and BRPF1 , respectively In Vitro IACS-9571 Hydrochloride shows excellent cellular potency with EC 50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (K d =1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 8 nM (TRIM24), Kd: 31 nM (TRIM24), 14 nM (BRPF1) |
| Canonical SMILES | CCCOC1=CC(=CC(=C1)OC2=CC3=C(C=C2NS(=O)(=O)C4=CC(=C(C=C4)OC)OC)N(C(=O)N3C)C)OCCCCN(C)C.Cl |
|---|---|
| Molecular Weight | 679.22 |
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