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Ibotenic acid - ≥95%, high purity , CAS No.2552-55-8, Agonist of mGlu 1 receptor;Agonist of mGlu 5 receptor

Moligand™
≥95%

CAS#: 2552-55-8
Formula: C₅H₆N₂O₄
Molecular Weight: 158.11
PubChem CID: 1233
PubChem SID: 488179610

Item Number

A137136

Grouped product items
SKU	Size	Availability	Price
A137136-1mg	1mg	In stock	$49.90
A137136-5mg	5mg	In stock	$205.90
A137136-10mg	10mg	In stock	$369.90
A137136-25mg	25mg	In stock	$804.90
A137136-50mg	50mg	In stock	$1,414.90

Excitotoxic agonist

View related series

mGlu1 receptor Agonist mGlu5 receptor Agonist

Basic Description

Synonyms	Ibotenic acid\|2552-55-8\|Ibotenate\|(+/-)-Ibotenic acid\|DL-Ibotenic acid\|(RS)-Ibotenic acid\|2-amino-2-(3-oxo-2,3-dihydroisoxazol-5-yl)acetic acid\|alpha-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic acid\|NSC204850\|2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid\|44A
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of mGlu 1 receptor;Agonist of mGlu 5 receptor
Product Description	Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

Associated Targets

GRM1 Tchem Metabotropic glutamate receptor 1 0 Activities

Discover Target: GRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 1 Activities

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488179610
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179610
IUPAC Name	2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
INCHI	InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
InChi Key	IRJCBFDCFXCWGO-UHFFFAOYSA-N
Canonical SMILES	C1=C(ONC1=O)C(C(=O)O)N
Isomeric SMILES	C1=C(ONC1=O)C(C(=O)O)N
PubChem CID	1233
Molecular Weight	158.11

PubChem CID

CAS Registry No.

Wikipedia

BindingDB Ligand

ChEMBL Ligand

ChEBI

GPCRdb Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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9 results found

Lot Number	Certificate Type	Date	Item
E2316116	Certificate of Analysis	Mar 10, 2023	A137136
E2316118	Certificate of Analysis	Mar 10, 2023	A137136
E2316119	Certificate of Analysis	Mar 10, 2023	A137136
E2316121	Certificate of Analysis	Mar 10, 2023	A137136
E2316123	Certificate of Analysis	Mar 10, 2023	A137136
E2316124	Certificate of Analysis	Mar 10, 2023	A137136
E2316125	Certificate of Analysis	Mar 10, 2023	A137136
E2316126	Certificate of Analysis	Mar 10, 2023	A137136
D2015066	Certificate of Analysis	Feb 17, 2022	A137136

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.

References

1. Murray JE et al.. (2015) Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.. Nat Commun, 6 (10088). [PMID:26657320]
2. Masini CV et al.. (2012) Auditory cortex lesions do not disrupt habituation of HPA axis responses to repeated noise stress.. Brain Res, 1443 (18-26). [PMID:22290179]
3. Poliwoda A et al.. (2014) Determination of muscimol and ibotenic acid in mushrooms of Amanitaceae by capillary electrophoresis.. Electrophoresis, 35 (18): (2593-9). [PMID:24981810]
4. Hunsaker MR et al.. (2008) Dissociating the roles of dorsal and ventral CA1 for the temporal processing of spatial locations, visual objects, and odors.. Behav Neurosci, 122 (3): (643-50). [PMID:18513134]
5. Guitchounts G et al.. (2020) Encoding of 3D Head Orienting Movements in the Primary Visual Cortex.. Neuron, 108 (3): (512-525.e4). [PMID:32783881]
6. Hunsaker MR & Kesner RP. (2008) Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and dorsal CA1 during a temporal ordering for spatial locations task.. Hippocampus, 18 (9): (955-64). [PMID:18493930]
7. Hunsaker MR et al.. (2008) Evaluating the temporal context of episodic memory: the role of CA3 and CA1.. Behav Brain Res, 188 (2): (310-5). [PMID:18178264]
8. Guirado R et al.. (2016) Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex.. Cereb Cortex, 26 (3): (1287-94). [PMID:26637448]
9. Ruediger S et al.. (2012) Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning.. Nat Neurosci, 15 (11): (1563-71). [PMID:23001061]
10. Roberts TF et al.. (2012) Motor circuits are required to encode a sensory model for imitative learning.. Nat Neurosci, 15 (10): (1454-9). [PMID:22983208]
11. Tanaka YH et al.. (2018) Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning.. Neuron, 100 (244-258.e12). [PMID:30174116]
12. Hunsaker MR et al.. (2008) The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty.. Hippocampus, 18 (10): (1064-73). [PMID:18651615]
13. Pelloux Y et al.. (2014) The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation.. Front Behav Neurosci, 8 (414). [PMID:25538581]

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