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Ibuprofen - ≥98%(GC), high purity , CAS No.15687-27-1, Channel blocker of ASIC1;Inhibitor of COX-1;Inhibitor of COX-2;Agonist of Peroxisome proliferator-activated receptor-γ;Inhibitor of SMCT1

  • Moligand™
  • ≥98%(GC)
Item Number
I129291
Grouped product items
SKUSizeAvailabilityPrice Qty
I129291-25g
25g
In stock
$9.90
I129291-100g
100g
In stock
$14.90
I129291-250g
250g
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$32.90
I129291-500g
500g
In stock
$57.90

A nonsteroidal anti-inflammatory drug (NSAID). COX inhibitor.

Basic Description

Synonymsibuprofen|15687-27-1|2-(4-Isobutylphenyl)propanoic acid|Motrin|Brufen|Advil|Nurofen|Dolgit|Liptan|Medipren|Nuprin|Anflagen|Buburone|Butylenin|Ibuprocin|Lamidon|Ebufac|Ibumetin|Mynosedin|Roidenin|Andran|Apsifen|Bluton|Epobron|Haltran|Nobfen|Nobgen|Trendar|
Specifications & PurityMoligand™, ≥98%(GC)
Biochemical and Physiological MechanismsCyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.A nonsteroidal anti-inflammatory drug (NSAID). Non-selective inhibitor of COX-1 and COX-2 (IC 50 values are 12 and 80 µM respectively). Inhibits thromboxane B2 relea
Shipped InNormal
GradeMoligand™
Action TypeAGONIST, CHANNEL BLOCKER, INHIBITOR
Mechanism of actionChannel blocker of ASIC1;Inhibitor of COX-1;Inhibitor of COX-2;Agonist of Peroxisome proliferator-activated receptor-γ;Inhibitor of SMCT1
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.

Product Properties

ALogP3.5

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD4 Tchem D(4) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ELANE Tclin Neutrophil elastase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARB Tclin Retinoic acid receptor beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARA Tclin Retinoic acid receptor alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR7 Tclin 5-hydroxytryptamine receptor 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

F2 Tclin Prothrombin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EDNRB Tclin Endothelin receptor type B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TACR1 Tclin Substance-P receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NOS1 Tchem Nitric oxide synthase, brain 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488179781
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179781
IUPAC Name 2-[4-(2-methylpropyl)phenyl]propanoic acid
INCHI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
InChi Key HEFNNWSXXWATRW-UHFFFAOYSA-N
Canonical SMILES CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
Isomeric SMILES CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
WGK Germany 3
RTECS MU6640000
Alternate CAS 31121-93-4
PubChem CID 3672
Molecular Weight 206.28

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

39 results found

Lot NumberCertificate TypeDateItem
F2421551Certificate of AnalysisJun 07, 2024 I129291
F2421552Certificate of AnalysisJun 07, 2024 I129291
F2421556Certificate of AnalysisJun 07, 2024 I129291
F2421560Certificate of AnalysisJun 07, 2024 I129291
F2421559Certificate of AnalysisJun 07, 2024 I129291
F2421558Certificate of AnalysisJun 07, 2024 I129291
F2421557Certificate of AnalysisJun 07, 2024 I129291
C2414620Certificate of AnalysisMar 02, 2024 I129291
C2414621Certificate of AnalysisMar 02, 2024 I129291
C2414628Certificate of AnalysisMar 02, 2024 I129291
C2226255Certificate of AnalysisJan 05, 2024 I129291
K2328447Certificate of AnalysisNov 17, 2023 I129291
K2328454Certificate of AnalysisNov 17, 2023 I129291
D2422081Certificate of AnalysisNov 17, 2023 I129291
K2328488Certificate of AnalysisNov 17, 2023 I129291
K2328489Certificate of AnalysisNov 17, 2023 I129291
D2403057Certificate of AnalysisNov 17, 2023 I129291
C2304666Certificate of AnalysisFeb 15, 2023 I129291
C2304786Certificate of AnalysisFeb 15, 2023 I129291
C2304507Certificate of AnalysisFeb 15, 2023 I129291
C2304497Certificate of AnalysisFeb 15, 2023 I129291
C2304505Certificate of AnalysisFeb 15, 2023 I129291
C2304504Certificate of AnalysisFeb 15, 2023 I129291
C2304498Certificate of AnalysisFeb 15, 2023 I129291
A2303380Certificate of AnalysisJan 07, 2023 I129291
A2303391Certificate of AnalysisJan 07, 2023 I129291
A2107092Certificate of AnalysisOct 24, 2022 I129291
D2422082Certificate of AnalysisAug 24, 2022 I129291
I2304094Certificate of AnalysisAug 24, 2022 I129291
J2210526Certificate of AnalysisAug 24, 2022 I129291
J2210527Certificate of AnalysisAug 24, 2022 I129291
J2210528Certificate of AnalysisAug 24, 2022 I129291
J2210529Certificate of AnalysisAug 24, 2022 I129291
J2210530Certificate of AnalysisAug 24, 2022 I129291
C2226265Certificate of AnalysisFeb 25, 2022 I129291
C2226243Certificate of AnalysisFeb 25, 2022 I129291
C2226297Certificate of AnalysisFeb 25, 2022 I129291
C2226306Certificate of AnalysisFeb 25, 2022 I129291
A2219177Certificate of AnalysisFeb 14, 2022 I129291

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Chemical and Physical Properties

SolubilitySoluble in ethanol (25 mg/ml), chloroform (1:1), ether (1:2), acetone (1:1.5), aqueous solutions of alkali hydroxides and carbonates, dichloromethane, methanol (50 mg/ml), and ethyl acetate. Insoluble in water.
Boil Point(°C)157°C/4mmHg
Melt Point(°C)75-78℃

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS MU6640000
Merck Index 4881

Related Documents

Solution Calculators