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ICA-105574 - 98%, high purity , CAS No.316146-57-3, Gating inhibitor of K v10.1;Activator of K v11.1

Moligand™
≥98%

CAS#: 316146-57-3
Formula: C₁₉H₁₄N₂O₄
Molecular Weight: 334.33
PubChem CID: 715924

Item Number

I413105

Grouped product items
SKU	Size	Availability	Price
I413105-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$975.90
I413105-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,035.90
I413105-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
I413105-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,364.90
I413105-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,582.90

View related series

Kv10.1 Gating inhibitor Kv11.1 Activator

Basic Description

Synonyms	ICA-105574\|3-nitro-N-(4-phenoxyphenyl)benzamide\|316146-57-3\|3-nitro-N-[4-(phenoxy)phenyl]benzamide\|ICA105574\|ICA 105574\|Oprea1_425613\|Oprea1_777421\|GTPL7656\|CHEMBL4575751\|DTXSID80351981\|EX-A4991\|STL377841\|AKOS001414914\|3-nitro-N-[4-phenoxyphenyl]-benzamid
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR, GATING INHIBITOR
Mechanism of action	Gating inhibitor of K v10.1;Activator of K v11.1
Product Description	Information ICA-105574 (ICA, 3-nitro-N-[4-phenoxyphenyl]-benzamide) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. ICA-105574 also modulates activation kinetics of the channel.

Associated Targets

KCNH1 Tclin Potassium voltage-gated channel subfamily H member 1 1 Activities

Discover Target: KCNH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-nitro-N-(4-phenoxyphenyl)benzamide
INCHI	InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
InChi Key	GDWKBKTVROCPNZ-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)[N+](=O)[O-]
Isomeric SMILES	C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)[N+](=O)[O-]
PubChem CID	715924
Molecular Weight	334.33

PubChem CID

715924

CAS Registry No.

316146-57-3

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
L2320061	Certificate of Analysis	Dec 08, 2023	I413105
L2320062	Certificate of Analysis	Dec 08, 2023	I413105
L2320065	Certificate of Analysis	Dec 08, 2023	I413105
L2320070	Certificate of Analysis	Dec 08, 2023	I413105
L2320072	Certificate of Analysis	Dec 08, 2023	I413105
L2320073	Certificate of Analysis	Dec 08, 2023	I413105

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H317:May cause an allergic skin reaction H400:Very toxic to aquatic life
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.

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