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IDRA-21 - ≥98%, high purity , CAS No.22503-72-6, Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

Moligand™
≥98%

CAS#: 22503-72-6
Formula: C₈H₉ClN₂O₂S
Molecular Weight: 232.69
EC Number: 839-213-6
MDL number: MFCD00270874
PubChem CID: 3688

Item Number

I137115

Grouped product items
SKU	Size	Availability	Price
I137115-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$10.90
I137115-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$27.90
I137115-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$85.90

Inhibits AMPA desensitization

View related series

GluA1 Allosteric modulator GluA2 Allosteric modulator GluA3 Allosteric modulator GluA4 Allosteric modulator

Basic Description

Synonyms	22503-72-6\|idra 21\|Idra-21\|7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide\|7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide\|7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide\|689UW7PT68\|MFCD00270
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier thancyclothiazide.Blocks the rapid desensitization of the AMPA receptors and markedly prolongs the decay time of the evoked ex
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA4 Tclin Glutamate receptor 4 0 Activities

Discover Target: GRIA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA2 Tclin Glutamate receptor 2 0 Activities

Discover Target: GRIA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 0 Activities

Discover Target: GRIA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA1 Tclin Glutamate receptor 1 0 Activities

Discover Target: GRIA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-chloro-3-methyl-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine 1,1-dioxide
INCHI	InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
InChi Key	VZRNTCHTJRLTMU-UHFFFAOYSA-N
Canonical SMILES	CC1NC2=C(C=C(C=C2)Cl)S(=O)(=O)N1
Isomeric SMILES	CC1NC2=C(C=C(C=C2)Cl)S(=O)(=O)N1
WGK Germany	3
Alternate CAS	163936-78-5,22503-72-6,163936-79-6
PubChem CID	3688
MeSH Entry Terms	7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide;IDRA 21;IDRA-21
Molecular Weight	232.69

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3 results found

Lot Number	Certificate Type	Date	Item
I2203321	Certificate of Analysis	Jun 18, 2024	I137115
I2203322	Certificate of Analysis	Jun 18, 2024	I137115
I2203323	Certificate of Analysis	Jun 18, 2024	I137115

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