IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) ( IC 50 =2-8 μM).
In Vitro
IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.