Grouped product items

SKU

Size

Availability

Price

Qty

I124859-10mg

10mg

Available within 4-8 weeks(?)

$75.90

I124859-25mg

25mg

Available within 4-8 weeks(?)

$171.90

I124859-50mg

50mg

Available within 4-8 weeks(?)

$271.90

I124859-250mg

250mg

Available within 4-8 weeks(?)

$1,224.90

I124859-1g

Available within 4-8 weeks(?)

$4,406.90

I124859-5g

Available within 4-8 weeks(?)

$19,828.90

I124859-25g

25g

Available within 4-8 weeks(?)

$89,229.90

Basic Description

Synonyms	Iguratimod\|123663-49-0\|N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide\|Careram\|Kolbet\|T-614\|Iguratimod [INN]\|Iremod\|4IHY34Y2NV\|DTXSID0048971\|3-Formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one\|NCGC00181783-02\|T614\|N-[7-(
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Cyclooxygenase-2 inhibitor
Note	25/250mg卖完停产，不再备货
Product Description	Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.

Product Properties

ALogP	1.4

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 0 Activities

Discover Target: DRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

Discover Target: SLC6A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

Discover Target: SLC6A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PGR Tclin Progesterone receptor 0 Activities

Discover Target: PGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

Discover Target: PDE4D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

Discover Target: PDE3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

Discover Target: PDE4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MIF Tchem Macrophage migration inhibitory factor 0 Activities

Discover Target: MIF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC3R Tchem Melanocortin receptor 3 0 Activities

Discover Target: MC3R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

Discover Target: NR1I2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

Discover Target: ADRA2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Discover Target: ADRA1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Discover Target: HTR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Discover Target: ADORA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Discover Target: HTR2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

Discover Target: TBXA2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2 Tclin Prothrombin 0 Activities

Discover Target: F2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Discover Target: OPRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Discover Target: OPRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[7-(methanesulfonamido)-4-oxo-6-phenoxychromen-3-yl]formamide
INCHI	InChI=1S/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20)
InChi Key	ANMATWQYLIFGOK-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
Isomeric SMILES	CS(=O)(=O)NC1=C(C=C2C(=C1)OC=C(C2=O)NC=O)OC3=CC=CC=C3
PubChem CID	124246
Molecular Weight	374.37

Database links

ChEMBL Ligand	CHEMBL2107455
PubChem CID	124246
CAS Registry No.	123663-49-0
DrugCentral Ligand	4894

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot Number	Certificate Type	Date	Item
G2215378	Certificate of Analysis	Apr 07, 2024	I124859
G2215382	Certificate of Analysis	Apr 07, 2024	I124859
G2215383	Certificate of Analysis	Apr 07, 2024	I124859
G2215746	Certificate of Analysis	Apr 07, 2024	I124859
G2215753	Certificate of Analysis	Apr 07, 2024	I124859
F1730073	Certificate of Analysis	Jan 18, 2023	I124859
D2106029	Certificate of Analysis	Jan 15, 2023	I124859
L1804143	Certificate of Analysis	Aug 08, 2022	I124859

Chemical and Physical Properties

Solubility	DMSO
Sensitivity	Hygroscopic
Melt Point(°C)	240 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice.

FAQs and Articles

FAQ

RNA Viruses Triggered Signal Pathway

Categories: Technical articles

Tags:

NF-kB signaling pathway Signaling pathway RNA virus NF-kB

References

1. Aikawa Y, Yamamoto M, Yamamoto T, Morimoto K, Tanaka K. (2002) An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and TNF-alpha-stimulated THP-1 cells without interfering with IkappaBalpha degradation.. Inflamm Res, 51 (4): (188-94). [PMID:12058956]
2. Greven D, Leng L, Bucala R. (2010) Autoimmune diseases: MIF as a therapeutic target.. Expert Opin Ther Targets, 14 (3): (253-64). [PMID:20148714]
3. Mucke HA. (2012) Iguratimod: a new disease-modifying antirheumatic drug.. Drugs Today, 48 (9): (577-86). [PMID:23032798]
4. Luo Q, Sun Y, Liu W, Qian C, Jin B, Tao F, Gu Y, Wu X, Shen Y, Xu Q. (2013) A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.. J Immunol, 191 (10): (4969-78). [PMID:24123677]
5. Jiang XP, Huang XL, Yang ZP, Wang SC, Xie W, Miao L, Tang L, Huang ZM. (2018) Iguratimod ameliorates inflammatory responses by modulating the Th17/Treg paradigm in dextran sulphate sodium-induced murine colitis.. Mol Immunol, 93 (3): (9-19). [PMID:29121519]
6. Bloom J, Metz C, Nalawade S, Casabar J, Cheng KF, He M, Sherry B, Coleman T, Forsthuber T, Al-Abed Y. (2016) Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential.. J Biol Chem, 291 (51): (26502-26514). [PMID:27793992]

Solution Calculators

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SKU	Size	Availability	Price
I124859-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$75.90
I124859-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$171.90
I124859-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$271.90
I124859-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,224.90
I124859-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$4,406.90
I124859-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$19,828.90
I124859-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$89,229.90

Iguratimod - ≥98%, high purity , Cyclooxygenase-2 inhibitor, CAS No.123663-49-0, Cyclooxygenase-2 inhibitor

Basic Description

Product Properties

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 0 Activities

ESR1 Tclin Estrogen receptor 0 Activities

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

HRH3 Tclin Histamine H3 receptor 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

HRH1 Tclin Histamine H1 receptor 0 Activities

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

PGR Tclin Progesterone receptor 0 Activities

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

MIF Tchem Macrophage migration inhibitory factor 0 Activities

MC3R Tchem Melanocortin receptor 3 0 Activities

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

DRD3 Tclin D(3) dopamine receptor 0 Activities

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

ACHE Tclin Acetylcholinesterase 0 Activities

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

AR Tclin Androgen receptor 0 Activities

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

ADORA3 Tchem Adenosine receptor A3 0 Activities

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

F2 Tclin Prothrombin 0 Activities

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

OPRD1 Tclin Delta-type opioid receptor 0 Activities

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

References

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