IKarisoside A - 99%, high purity , CAS No.55395-07-8

Item Number

I647153

• Synonyms: Baohuoside II|Ikarisoside A|55395-07-8|MLS000697625|5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one|SMR000470956|4H-1-Benzopyran-4-one, 3-((6-deoxy-alpha-L-mennopyranosyl)oxy
• Specifications & Purity: ≥99%
• Biochemical and Physiological Mechanisms: IKarisoside A (Icarisoside-A) is a natural flavonol glycoside and has anti-inflammatory properties.
• Storage Temp: Protected from light,Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

IKarisoside A (Icarisoside-A) is a natural flavonol glycoside and has anti-inflammatory properties.

In Vitro

Ikarisoside A inhibited the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and mouse bone marrow-derived macrophages (BMMs) in a concentration-dependent manner. In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Furthermore, Ikarisoside A inhibited the activity of p38 kinase and nuclear factor-kappaB (NF-kappaB). Ikarisoside A is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW 264.7 cells as well as in bone marrow-derived macrophages.The inhibitory effect of Ikarisoside A resulted in decrease of osteoclast-specific genes like matrix metalloproteinase 9 (MMP9), tartrate-resistant acid phosphatase (TRAP), receptor activator of NF-kappaB (RANK), and cathepsin K. Moreover, Ikarisoside A blocked the resorbing capacity of RAW 264.7 cells on calcium phosphate-coated plates. Ikarisoside A also has inhibitory effects on the RANKL-mediated activation of NF-kappaB, JNK, and Akt. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid