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IL-33, CAS No.rp174305, Agonist of Interleukin-33 receptor

  • Moligand™
Features and benefits
    Item Number
    rp174305
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp174305-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp174305-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
    View related series
    Interleukin-33 receptor Agonist

    Basic Description

    Product NameIL-33, CAS No.rp174305
    SynonymsIL-1F11
    GradeMoligand™
    Action TypeAGONIST
    Mechanism of actionAgonist of Interleukin-33 receptor

    Associated Targets

    IL1RL1 Tbio Interleukin-1 receptor-like 1 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    IL1RAP Tclin Interleukin-1 receptor accessory protein 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp174305

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesIL-1F11
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Hsu CL, Neilsen CV, Bryce PJ.  (2010)  IL-33 is produced by mast cells and regulates IgE-dependent inflammation..  PLoS ONE,  (8): (e11944).  [PMID:20689814]
    2. Lefrançais E, Cayrol C.  (2012)  Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members..  Eur Cytokine Netw,  23  (4): (120-7).  [PMID:23306193]
    3. Cayrol C, Girard JP.  (2014)  IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy..  Curr Opin Immunol,  31  (3): (31-7).  [PMID:25278425]
    4. Bandara G, Beaven MA, Olivera A, Gilfillan AM, Metcalfe DD.  (2015)  Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33..  Eur J Immunol,  45  (11): (3034-44).  [PMID:26256265]
    5. Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM et al..  (2020)  Cellular context of IL-33 expression dictates impact on anti-helminth immunity..  Sci Immunol,  (53): (589-97).  [PMID:33188058]
    6. Chen YL, Gutowska-Owsiak D, Hardman CS, Westmoreland M, MacKenzie T, Cifuentes L, Waithe D, Lloyd-Lavery A, Marquette A, Londei M et al..  (2019)  Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis..  Sci Transl Med,  11  (515): (589-97).  [PMID:31645451]

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