iMAC2 , CAS No.335166-00-2

Item Number
I342366
Grouped product items
SKUSizeAvailabilityPrice Qty
I342366-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$223.90
I342366-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$902.90

Discover iMAC2 by Aladdin Scientific in for only $223.90. Available - in Ligands at Aladdin Scientific. a mitochondrial apoptosis-induced channel (MAC) inhibitor Tags: .

Basic Description

Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

iMAC2 inhibits mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). It has been shown to reduce STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).

Names and Identifiers

IUPAC Name 3,6-dibromo-9-(2-fluoro-3-piperazin-1-ylpropyl)carbazole;dihydrochloride
INCHI InChI=1S/C19H20Br2FN3.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)25(18)12-15(22)11-24-7-5-23-6-8-24;;/h1-4,9-10,15,23H,5-8,11-12H2;2*1H
InChi Key JWCVUOLQOHIRML-UHFFFAOYSA-N
Canonical SMILES C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)F.Cl.Cl
Isomeric SMILES C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)F.Cl.Cl
PubChem CID 90488878
Molecular Weight 469.1923646

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (5 mM).

Related Documents

Solution Calculators