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Imidaprilat , CAS No.89371-44-8, Inhibitor of Angiotensin-converting enzyme

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Imidaprilat , CAS No.89371-44-8, Inhibitor of Angiotensin-converting enzyme

Moligand™

CAS#: 89371-44-8
Formula: C₁₈H₂₃N₃O₆
Molecular Weight: 377.39
PubChem CID: 5464344

Item Number

I353376

Grouped product items
SKU	Size	Availability	Price	Qty
I353376-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$305.90

an ACE ihibitor

View related series

Angiotensin-converting enzyme Inhibitor

Basic Description

Synonyms	Imidaprilat\|89371-44-8\|Imidaprilate\|Imidapril Diacid\|WUU07Y30IA\|CHEMBL99701\|6366A\|(4S)-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid\|6366A; Imidaprilat\|(4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Angiotensin-converting enzyme
Product Description	Imiddaprilat is an antihypertensive compound that inhibits the catalytic activity of angiotensin-converting enzyme (ACE). This prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.

Product Properties

pKa	pKa: 2.17 (Predicted), pKa: 7.12 (Predicted)

Associated Targets

ACE Tclin Angiotensin-converting enzyme 2 Activities

Discover Target: ACE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(4S)-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
INCHI	InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1
InChi Key	VFAVNRVDTAPBNR-UBHSHLNASA-N
Canonical SMILES	CC(C(=O)N1C(CN(C1=O)C)C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O
Isomeric SMILES	C[C@@H](C(=O)N1[C@@H](CN(C1=O)C)C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O
PubChem CID	5464344
Molecular Weight	377.39

Database links

PubChem CID	5464344
CAS Registry No.	89371-44-8
ChEMBL Ligand	CHEMBL99701
Reactome Reaction	R-HSA-9614933, R-HSA-9619034
Reactome Drug	R-ALL-9614914, R-ALL-9619026

Certificates

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Chemical and Physical Properties

Solubility	Soluble in water, methanol, and DMSO.
Refractive Index	n20D1.59 (Predicted)
Boil Point(°C)	~592.1° C at 760 mmHg (Predicted)
Melt Point(°C)	>224° C

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