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INCB3284 , CAS No.887401-92-5, Antagonist of CCR2

Item Number

I611055

Grouped product items
SKU	Size	Availability	Price	Qty
I611055-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I611055-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	INCB 3284\|887401-92-5\|UNII-0W6K09GAQB\|INCB3284\|INCB-3284\|0W6K09GAQB\|CHEMBL1963131\|INCB-003284\|Benzamide, N-(2-(((3R)-1-(trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl)-3-pyrrolidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)-\|N-[2-[[(3R)-1-[4-hydroxy-4-
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
INCHI	InChI=1S/C26H31F3N4O4/c1-37-23-6-5-19(14-30-23)25(36)10-7-21(8-11-25)33-12-9-20(16-33)32-22(34)15-31-24(35)17-3-2-4-18(13-17)26(27,28)29/h2-6,13-14,20-21,36H,7-12,15-16H2,1H3,(H,31,35)(H,32,34)/t20-,21?,25?/m1/s1
InChi Key	NXZNYBUBXWWKCP-JMOWIOHXSA-N
Canonical SMILES	COc1ccc(cn1)C1(O)CCC(CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F
Isomeric SMILES	COC1=NC=C(C=C1)C2(CCC(CC2)N3CC[C@H](C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O
PubChem CID	11527661

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1. Xue CB, Feng H, Cao G, Huang T, Glenn J, Anand R, Meloni D, Zhang K, Kong L, Wang A et al.. (2011) Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist.. ACS Med Chem Lett, 2 (6): (450-4). [PMID:24900329]

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