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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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I288666-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $89.90 | |
I288666-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $121.90 | |
I288666-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $219.90 | |
I288666-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $513.90 |
Positive allosteric modulator of GABAA; acts at benzodiazepine site
Synonyms | Calenthys | CAS_325715-02-4 | GTPL4221 | HMS3678A19 | NCGC00346880-01 | N-methyl-N-{3-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}acetamide | N-methyl-N-{3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}acetamide | HMS34 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent GABAAreceptor positive allosteric modulator that acts at the benzodiazepine site (Kivalues are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity forα1 subunit-containing receptors (EC50values are 2.6, |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR, POSITIVE ALLOSTERIC MODULATOR |
Mechanism of action | GABA receptor alpha-1 subunit positive allosteric modulator |
ALogP | 2.3 |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide |
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INCHI | InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 |
InChi Key | CBIAWPMZSFFRGN-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4 |
Isomeric SMILES | CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4 |
PubChem CID | 6450813 |
Molecular Weight | 376.43 |
Wikipedia | Indiplon |
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CAS Registry No. | 325715-02-4 |
PubChem CID | 6450813 |
ChEMBL Ligand | CHEMBL262075 |
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Lot Number | Certificate Type | Date | Item |
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C2419338 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419339 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419340 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419341 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419342 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419343 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419344 | Certificate of Analysis | Jan 22, 2024 | I288666 |
C2419345 | Certificate of Analysis | Jan 22, 2024 | I288666 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 18.82, Max Conc. mM: 50 |
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