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Indiplon - 98%, high purity , GABA receptor alpha-1 subunit positive allosteric modulator, CAS No.325715-02-4, GABA receptor alpha-1 subunit positive allosteric modulator

  • Moligand™
  • ≥98%
Item Number
I288666
Grouped product items
SKUSizeAvailabilityPrice Qty
I288666-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
I288666-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$121.90
I288666-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$219.90
I288666-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$513.90

Positive allosteric modulator of GABAA; acts at benzodiazepine site

Basic Description

SynonymsCalenthys | CAS_325715-02-4 | GTPL4221 | HMS3678A19 | NCGC00346880-01 | N-methyl-N-{3-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}acetamide | N-methyl-N-{3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}acetamide | HMS34
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent GABAAreceptor positive allosteric modulator that acts at the benzodiazepine site (Kivalues are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity forα1 subunit-containing receptors (EC50values are 2.6,
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeALLOSTERIC MODULATOR, POSITIVE ALLOSTERIC MODULATOR
Mechanism of actionGABA receptor alpha-1 subunit positive allosteric modulator

Product Properties

ALogP2.3

Associated Targets

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide
INCHI InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
InChi Key CBIAWPMZSFFRGN-UHFFFAOYSA-N
Canonical SMILES CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4
Isomeric SMILES CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4
PubChem CID 6450813
Molecular Weight 376.43

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
C2419338Certificate of AnalysisJan 22, 2024 I288666
C2419339Certificate of AnalysisJan 22, 2024 I288666
C2419340Certificate of AnalysisJan 22, 2024 I288666
C2419341Certificate of AnalysisJan 22, 2024 I288666
C2419342Certificate of AnalysisJan 22, 2024 I288666
C2419343Certificate of AnalysisJan 22, 2024 I288666
C2419344Certificate of AnalysisJan 22, 2024 I288666
C2419345Certificate of AnalysisJan 22, 2024 I288666

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 18.82, Max Conc. mM: 50

Related Documents

Solution Calculators