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Indirubin - analytical standard，≥95%, high purity , CAS No.479-41-4

2 Citations

analytical standard

≥95%

CAS#: 479-41-4
Formula: C₁₆H₁₀N₂O₂
Molecular Weight: 262.26
PubChem CID: 10177

Item Number

I111267

Grouped product items
SKU	Size	Availability	Price
I111267-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$48.90
I111267-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$76.90
I111267-20mg	20mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$121.90
I111267-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$268.90
I111267-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$481.90

Potent cyclin-dependent kinase and GSK-3β inhibitor

Basic Description

Synonyms	(3Z)-3-(3-oxoindolin-2-ylidene)indolin-2-one \| 2H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-, (3E)- \| AKOS032455876 \| KBioGR_000450 \| DB12379 \| (3E)-3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one \| HMS2234G06 \|
Specifications & Purity	analytical standard，≥95%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	analytical standard
Product Description	Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10μM), CDK2/cyclin A (IC50 = 2.2μM), CDK2/cyclin E (IC50 = 7.5μM), CDK4/cyclin D1 (IC50 = 12μM), CDK5/p35 (IC50 = 5.5μM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model. An inhibitor of GSK-3β and cyclin-dependent kinases.

Names and Identifiers

IUPAC Name	2-(2-hydroxy-1H-indol-3-yl)indol-3-one
INCHI	InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,18,20H
InChi Key	JNLNPCNGMHKCKO-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O
Isomeric SMILES	C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=O
PubChem CID	10177
Molecular Weight	262.26

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
F2221286	Certificate of Analysis	Mar 15, 2024	I111267
F2221287	Certificate of Analysis	Mar 15, 2024	I111267
F2221402	Certificate of Analysis	Mar 15, 2024	I111267
F2221404	Certificate of Analysis	Mar 15, 2024	I111267
D2108267	Certificate of Analysis	Jan 12, 2023	I111267

Solubility

Soluble in DMSO(warmed) (>2 mg/ml).

Sensitivity

Heat sensitive.

Melt Point(°C)

350°C(lit.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

1. Mingyi Yao, Jian Liu, Narengaowa, Yonggu Li, Feng Zhao. (2023) In situ detection of natural dyes in archaeological textiles by SERS substrates immobilized on the fiber. MICROCHEMICAL JOURNAL, 192 (108939). [PMID:]
2. Sun Bing-Yao, Sui Hua-Lu, Liu Zi-Wei, Tao Xin-Yi, Gao Bei, Zhao Ming, Ma Yu-Shu, Zhao Jian, Liu Min, Wang Feng-Qing, Wei Dong-Zhi. (2022) Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin. Bioresources and Bioprocessing, 9 (1): (1-16). [PMID:38647553]

References

1. Mingyi Yao, Jian Liu, Narengaowa, Yonggu Li, Feng Zhao. (2023) In situ detection of natural dyes in archaeological textiles by SERS substrates immobilized on the fiber. MICROCHEMICAL JOURNAL, 192 (108939). [PMID:]
2. Sun Bing-Yao, Sui Hua-Lu, Liu Zi-Wei, Tao Xin-Yi, Gao Bei, Zhao Ming, Ma Yu-Shu, Zhao Jian, Liu Min, Wang Feng-Qing, Wei Dong-Zhi. (2022) Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin. Bioresources and Bioprocessing, 9 (1): (1-16). [PMID:38647553]

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