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Integrin alpha 4/CD49D Rat mA - Primary antibody, specific to Integrin alpha 4/CD49D, Rat IgG2b

  • Azide Free
  • Carrier Free
  • Validated
  • ≥95%(SDS-PAGE)
  • Lot by Lot
Features and benefits
  • Short Overview:

    mAb (PS/2); Rat anti Mouse/Human Integrin alpha 4/CD49D Antibody; Flow, in vivo VLA-4 neutralization, in vitro VLA-4 neutralization; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse
  • Isotype: Rat IgG2b
    Application:
  • Animal Model
  • Flow Cytometry
  • Functional Assay
  • Neutralization
Item Number
Ab110790
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab110790-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
Ab110790-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab110790-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
Ab110790-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90

mAb (PS/2); Rat anti Mouse/Human Integrin alpha 4/CD49D Antibody; Flow, in vivo VLA-4 neutralization, in vitro VLA-4 neutralization; Unconjugated

Basic Description

Product NameIntegrin alpha 4/CD49D Rat mA - Primary antibody, specific to Integrin alpha 4/CD49D, Rat IgG2b
Specifications & PurityValidated, Azide Free, Carrier Free, ≥95%(SDS-PAGE), Lot by Lot
Host speciesRat
SpecificityIntegrin alpha 4/CD49D
ImmunogenMouse P815 mast cells
ConjugationUnconjugated
GradeAzide Free, Carrier Free, Validated
Product Description

Rat anti Mouse/Human Integrin alpha 4/CD49D Antibody, Monoclonal (PS/2), could be used for Flow, in vivo VLA-4 neutralization, in vitro VLA-4 neutralization and so on.
Application:
Flow: Use at an assay dependent concentration.
in vivo VLA-4 neutralization: Use at an assay dependent concentration.
in vitro VLA-4 neutralization: Use at an assay dependent concentration.
Protein Function
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Product Properties

IsotypeRat IgG2b
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein G purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at 2-8°C,Freeze prohibited
Shipped InWet ice
Stability And StorageShipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon delivery aliquot.

Images

Integrin alpha 4/CD49D Rat mAb (Ab110790) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin alpha 4/CD49D with Integrin alpha 4/CD49D Rat mAb (Ab110790) conjugated with biotin (right panel) at 0.5 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Biotin) (Ab180310) (left panel) and detected with SA-PE (rp156150).

Integrin alpha 4/CD49D Rat mAb (Ab110790) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin alpha 4/CD49D (red) with Integrin alpha 4/CD49D Rat mAb (Ab110790) conjugated with biotin at 0.5 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.

Associated Targets

ITGA4 Tclin Integrin alpha-4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
Flow

Use at an assay dependent concentration.

in vivo VLA-4 neutralization

Use at an assay dependent concentration.

in vitro VLA-4 neutralization

Use at an assay dependent concentration.

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0607436Certificate of AnalysisJun 26, 2024 Ab110790
ZJ24F0607435Certificate of AnalysisJun 26, 2024 Ab110790
ZJ24F0607434Certificate of AnalysisJun 26, 2024 Ab110790

Related Documents

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