Normal peripheral blood platelets and platelets from IPT patients
Positive Control
Flow: Human peripheral blood lymphocytes.
Conjugation
Unconjugated
Grade
Carrier Free, ExactAb™, Validated
Product Description
Mouse anti Human Integrin beta 3/CD61 Antibody, Monoclonal (HIP11), could be used for Flow and so on. Application: Flow:＜0.5 µg/100w cells Protein Function Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Product Properties
Isotype
Mouse IgG1
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Stability And Storage
Shipped at 4°C. Store at 4°C long term (36 months). Upon delivery aliquot.
ZJ24F0708502