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TKL:Tyrosine kinase-like
IRAK4 inhibitor 4b , CAS No.I611138, Inhibitor of interleukin 1 receptor associated kinase 4

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IRAK4 inhibitor 4b , CAS No.I611138, Inhibitor of interleukin 1 receptor associated kinase 4

Moligand™

PubChem CID: 44449334

Item Number

I611138

Grouped product items
SKU	Size	Availability	Price	Qty
I611138-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
I611138-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

interleukin 1 receptor associated kinase 4 Inhibitor

Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of interleukin 1 receptor associated kinase 4

Associated Targets

IRAK4 Tchem Interleukin-1 receptor-associated kinase 4 3 Activities

Discover Target: IRAK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IRAK1 Tchem Interleukin-1 receptor-associated kinase 1 1 Activities

Discover Target: IRAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide
INCHI	InChI=1S/C20H21N5O3/c1-27-19-13-14(25-9-11-28-12-10-25)5-6-17(19)23-20(26)18-4-2-3-15(22-18)16-7-8-21-24-16/h2-8,13H,9-12H2,1H3,(H,21,24)(H,23,26)
InChi Key	RAFFLDOJXQAJPF-UHFFFAOYSA-N
Canonical SMILES	COc1cc(ccc1NC(=O)c1cccc(n1)c1ccn[nH]1)N1CCOCC1
Isomeric SMILES	COC1=C(C=CC(=C1)N2CCOCC2)NC(=O)C3=CC=CC(=N3)C4=CC=NN4
PubChem CID	44449334

Database links

ChEMBL Ligand	CHEMBL256713
BindingDB Ligand	50373415
PubChem CID	44449334
RCSB PDB Ligand	DL1

Certificates

Certificate of Analysis(COA)

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References

1. Buckley GM, Gowers L, Higueruelo AP, Jenkins K, Mack SR, Morgan T, Parry DM, Pitt WR, Rausch O, Richard MD et al.. (2008) IRAK-4 inhibitors. Part 1: a series of amides.. Bioorg Med Chem Lett, 18 (11): (3211-4). [PMID:18474425]

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