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TKL:Tyrosine kinase-like
IRAK4 inhibitor rac-45 , CAS No.I611139, Inhibitor of interleukin 1 receptor associated kinase 4

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IRAK4 inhibitor rac-45 , CAS No.I611139, Inhibitor of interleukin 1 receptor associated kinase 4

Moligand™

PubChem CID: 25169383

Item Number

I611139

Grouped product items
SKU	Size	Availability	Price	Qty
I611139-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$900.90
I611139-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

interleukin 1 receptor associated kinase 4 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of interleukin 1 receptor associated kinase 4

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IRAK4 Tchem Interleukin-1 receptor-associated kinase 4 2 Activities

Discover Target: IRAK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IRAK1 Tchem Interleukin-1 receptor-associated kinase 1 0 Activities

Discover Target: IRAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-{6-chloroimidazo[1,2-a]pyridin-3-yl}-N-(pyrrolidin-3-yl)pyridin-2-amine
INCHI	InChI=1S/C16H16ClN5/c17-11-4-5-16-19-9-14(22(16)10-11)13-2-1-3-15(21-13)20-12-6-7-18-8-12/h1-5,9-10,12,18H,6-8H2,(H,20,21)
InChi Key	NAMQQRIYZTTYCJ-UHFFFAOYSA-N
Canonical SMILES	Clc1ccc2n(c1)c(cn2)c1cccc(n1)NC1CNCC1
Isomeric SMILES	C1CNCC1NC2=CC=CC(=N2)C3=CN=C4N3C=C(C=C4)Cl
PubChem CID	25169383

Database links

ChEMBL Ligand	CHEMBL401633
PubChem CID	25169383

Certificates

Certificate of Analysis(COA)

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References

1. Buckley GM, Fosbeary R, Fraser JL, Gowers L, Higueruelo AP, James LA, Jenkins K, Mack SR, Morgan T, Parry DM et al.. (2008) IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.. Bioorg Med Chem Lett, 18 (12): (3656-60). [PMID:18501603]

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