| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| I408314-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $221.90 |
TGF-beta/Smad Activators
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | Information Isoxazole 9 (ISX-9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β induced epithelial In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. In vivo In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. cell lines：MKN45, EBC-1, Hs746T, SNU-5, A549, SNU-1 and MKN74 Concentrations：~50 μM Incubation Time：48 h Powder Purity:≥98% |
| Canonical SMILES | O=C(NC1CC1)C2=NOC(=C2)C3=CC=CS3 |
|---|---|
| Molecular Weight | 234.27 |
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