Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab177904-100μg | 100μg | In stock | $69.90 | |
| Ab177904-1mg | 1mg | In stock | $339.90 | |
| Ab177904-5mg | 5mg | In stock | $859.90 | |
| Ab177904-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,369.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Itepekimab (anti-IL-33) - Primary antibody, specific to IL33, >95%, high purity, Human IgG4SP |
|---|---|
| Synonyms | C9orf26 antibody; CHROMOSOME 9 OPEN READING FRAME 26 antibody; DKFZp586H0523 antibody; DVS27 antibody; DVS27 related protein antibody; IL 1F11 antibody; IL 33 antibody; IL-1F11 antibody; IL-33 antibody; IL1F11 antibody; IL33 antibody; IL33_HUMAN antibody; |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | IL33 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Interleukin-33 inhibitor |
| Product Description | Itepekimab (anti-IL-33) is a monoclonal antibody of IL-33. Itepekimab (anti-IL-33) reduces airway inflammation and related tissue damage in previous clinical studies. Itepekimab (anti-IL-33) has potential application in asthma, chronic obstructive pulmonary disease (COPD) and atopic dermatitis (AD). |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.2 kDa (Light Chain) & 51.8 kDa (Heavy Chain), under reducing conditions; 195.4 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2226742-52-3 |
Itepekimab (anti-IL-33) (Ab177904) - ELISA
Immobilized Recombinant Human IL-33 Protein (rp169652) at 2.0 μg/mL can bind Itepekimab (anti-IL-33) (Ab177904) with the EC₅₀ of 45.69 ng/mL.
Itepekimab (anti-IL-33) (Ab177904) - SEC
The purity of Itepekimab (anti-IL-33) (Ab177904) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0404223 | Certificate of Analysis | Apr 08, 2024 | Ab177904 |
| ZJ24F0404222 | Certificate of Analysis | Apr 08, 2024 | Ab177904 |
| ZJ24F0404221 | Certificate of Analysis | Apr 08, 2024 | Ab177904 |
| 1. Osbourn M, Soares DC, Vacca F, Cohen ES, Scott IC, Gregory WF, Smyth DJ, Toivakka M, Kemter AM, le Bihan T et al.. (2017) HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.. Immunity, 47 (4): (739-751.e5). [PMID:29045903] |
| 2. Onda, H H and 7 more authors.. (1999) Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, [PMID:10566975] |
| 3. Baekkevold, Espen S ES and 9 more authors.. (2003) Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules.. The American journal of pathology, [PMID:12819012] |
| 4. Carriere, Virginie V and 7 more authors.. (2007) IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:17185418] |
| 5. Komai-Koma, Mousa M and 5 more authors.. (2007) IL-33 is a chemoattractant for human Th2 cells.. European journal of immunology, [PMID:17853410] |
| 6. Küchler, Axel M AM and 8 more authors.. (2008) Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.. The American journal of pathology, [PMID:18787100] |
| 7. Moussion, Christine C, Ortega, Nathalie N and Girard, Jean-Philippe JP.. (2008) The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?. PloS one, (6): [PMID:18836528] |
| 8. Cayrol, Corinne C and Girard, Jean-Philippe JP.. (2009) The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:19439663] |
| 9. Talabot-Ayer, Dominique D, Lamacchia, Céline C, Gabay, Cem C and Palmer, Gaby G.. (2009) Interleukin-33 is biologically active independently of caspase-1 cleavage.. The Journal of biological chemistry, (17): [PMID:19465481] |
| 10. Lüthi, Alexander U AU and 11 more authors.. (2009) Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.. Immunity, (17): [PMID:19559631] |
| 11. Hayakawa, Morisada M and 5 more authors.. (2009) Mature interleukin-33 is produced by calpain-mediated cleavage in vivo.. Biochemical and biophysical research communications, (11): [PMID:19596270] |
| 12. Lingel, Andreas and 7 more authors.. (2009) Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.. Structure (London, England : 1993), (14): [PMID:19836339] |
| 13. Hong, Jaewoo J and 10 more authors.. (2011) Identification of constitutively active interleukin 33 (IL-33) splice variant.. The Journal of biological chemistry, (3): [PMID:21454686] |
| 14. Ali, Shafaqat S and 6 more authors.. (2011) The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:21734074] |
| 15. Kakkar, Rahul R, Hei, Hillary H, Dobner, Stephan S and Lee, Richard T RT.. (2012) Interleukin 33 as a mechanically responsive cytokine secreted by living cells.. The Journal of biological chemistry, (24): [PMID:22215666] |
| 16. Liu, Xi X and 7 more authors.. (2013) Structural insights into the interaction of IL-33 with its receptors.. Proceedings of the National Academy of Sciences of the United States of America, (10): [PMID:23980170] |
