Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V127056-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $90.90 | |
V127056-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $155.90 | |
V127056-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $702.90 | |
V127056-100mg | 100mg | In stock | $1,263.90 | |
V127056-250mg | 250mg | In stock | $2,843.90 | |
V127056-1g | 1g | In stock | $10,235.90 |
Synonyms | Ivacaftor|873054-44-5|VX-770|Kalydeco|Ivacaftor (VX-770)|N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide|VX 770|ivacaftorum|CHEBI:66901|UNII-1Y740ILL1Z|Ivacaftor-d18|N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Ivacaftor is a CFTR activator (IC50 of 43 ± 38 nM). In some cells Ivacaftor was shown to increase CFTR channel open probability in the F508del processing and the G551D gating mutations. In cultured human CF bronchial epithelia (HBE) expressing the F551D g |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of CFTR |
Note | 5mg、50mg、10mg卖完停产,不再备货 |
Product Description | Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
ALogP | 5.6 |
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IUPAC Name | N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide |
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INCHI | InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) |
InChi Key | PURKAOJPTOLRMP-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C |
Isomeric SMILES | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C |
PubChem CID | 16220172 |
Molecular Weight | 392.49 |
PubChem CID | 16220172 |
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ChEBI | CHEBI:66901 |
CAS Registry No. | 873054-44-5 |
Wikipedia | Ivacaftor |
ChEMBL Ligand | CHEMBL2010601 |
DrugBank Ligand | DB08820 |
PEP | ivacaftor |
RCSB PDB Ligand | VX7 |
Reactome Reaction | R-HSA-5679000, R-HSA-5678992 |
Reactome Drug | R-ALL-5678956 |
DrugCentral Ligand | 4228 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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G1530068 | Certificate of Analysis | May 10, 2023 | V127056 |
L2014259 | Certificate of Analysis | Oct 15, 2022 | V127056 |
K2218877 | Certificate of Analysis | Aug 22, 2022 | V127056 |
K2218907 | Certificate of Analysis | Aug 22, 2022 | V127056 |
K2218908 | Certificate of Analysis | Aug 22, 2022 | V127056 |
Solubility | DMSO 78 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
1. Van Goor F, Hadida S, Grootenhuis PD, Burton B, Cao D, Neuberger T, Turnbull A, Singh A, Joubran J, Hazlewood A et al.. (2009) Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.. Proc Natl Acad Sci USA, 106 (44): (18825-30). [PMID:19846789] |
2. Eckford PD, Li C, Ramjeesingh M, Bear CE. (2012) Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.. J Biol Chem, 287 (44): (36639-49). [PMID:22942289] |