IWP-O1 - 10mM in DMSO, high purity , CAS No.2074607-48-8

Item Number

I422517

Grouped product items
SKU	Size	Availability	Price	Qty
I422517-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

PORCN Inhibitors

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells. Targets porcn (Cell-based assay) 80 pM(EC50) In vitro IWP-O1 has significantly improved metabolic stability. Cell Research(from reference) Cell lines：HeLa cells Concentrations：1 μM Incubation Time：24 h

Names and Identifiers

IUPAC Name	N-(5-phenylpyridin-2-yl)-2-(5-phenyl-4-pyridin-4-yltriazol-1-yl)acetamide
INCHI	InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)
InChi Key	GYYDQHBKIHQHEB-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5
Isomeric SMILES	C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5
PubChem CID	134154594
Molecular Weight	432.48

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
RIDADR	NONHforallmodesoftransport

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Basic Description