Skip to the beginning of the images gallery

JAK/HDAC-IN-1 - 98%, high purity , CAS No.2284621-75-4

≥98%

CAS#: 2284621-75-4
Formula: C₁₉H₂₁Cl₂N₇O₂
Molecular Weight: 450.3
PubChem CID: 138377596

Item Number

J650776

Grouped product items
SKU	Size	Availability	Price
J650776-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
J650776-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
J650776-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
J650776-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90

View related series

Cell Cycle/DNA Damage Epigenetics HDAC JAK JAK/STAT Signaling Protein Tyrosine Kinase/RTK Stem Cell/Wnt

Basic Description

Specifications & Purity	98%
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Product Description	JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC 50 s of 4 and 2 nM for JAK2 and HDAC , respectively In Vitro JAK/HDAC-IN-1 (Compound 8m) exhibits IC 50 s of 4.8, 7.4 and 49 nM for JAK1, JAK3 and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:JAK2 4 nM (IC 50 ) JAK1 4.8 nM (IC 50 ) JAK3 7.4 nM (IC 50 ) Tyk2 49 nM (IC 50 ) HDAC 2 nM (IC 50 ) HDAC2 14 nM (IC 50 ) HDAC6 120 nM (IC 50 ) HDAC8 2470 nM (IC 50 )

Associated Targets

HDAC6 Tclin Histone deacetylase 6 1 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 1 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 1 Activities

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 1 Activities

Discover Target: JAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 1 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-[4-[[5-chloro-4-(4-chloroanilino)pyrimidin-2-yl]amino]pyrazol-1-yl]-N-hydroxyhexanamide
INCHI	InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)
InChi Key	MTOQNLGMTJOJOF-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1NC2=NC(=NC=C2Cl)NC3=CN(N=C3)CCCCCC(=O)NO)Cl
Isomeric SMILES	C1=CC(=CC=C1NC2=NC(=NC=C2Cl)NC3=CN(N=C3)CCCCCC(=O)NO)Cl
PubChem CID	138377596
Molecular Weight	450.3

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.