JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Click Here for 5% Off Your First Aladdin Purchase!

྾

Home
Applications
Targets
Kinases
TK:Tyrosine kinase
JBJ-09-063 hydrochloride - ≥98%, high purity , CAS No.2820336-67-0(free base), Allosteric modulator of epidermal growth factor receptor

Skip to the end of the images gallery

Skip to the beginning of the images gallery

JBJ-09-063 hydrochloride - ≥98%, high purity , CAS No.2820336-67-0(free base), Allosteric modulator of epidermal growth factor receptor

Moligand™
≥98%

CAS#: 2820336-67-0(free base)
Formula: C₃₁H₂₉FN₄O₃S(free base)
Molecular Weight: 556.65(free base)

Item Number

J611228

Grouped product items
SKU	Size	Availability	Price	Qty
J611228-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$270.90
J611228-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$940.90

View related series

epidermal growth factor receptor Allosteric modulator

Basic Description

Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of epidermal growth factor receptor
Product Description	JBJ-09-063 hydrochloride is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. JBJ-09-063 hydrochloride effectively reduces EGFR, Akt and ERK1/2 phosphorylation. JBJ-09-063 hydrochloride is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 hydrochloride can be used for researching EGFR-mutant lung cancer.

Associated Targets

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Molecular Weight	556.65(free base)

Database links

PubChem CID	163358785

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Sensitivity	Moisture sensitive

References

1. To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA et al.. (2022) An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.. Nat Cancer, 3 (4): (402-417). [PMID:35422503]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.