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CMGC:Containing CDK, MAPK, GSK3, CLK families
JH-VIII-49 , CAS No.J611234, Inhibitor of cyclin dependent kinase 19;Inhibitor of cyclin dependent kinase 8

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JH-VIII-49 , CAS No.J611234, Inhibitor of cyclin dependent kinase 19;Inhibitor of cyclin dependent kinase 8

Moligand™

PubChem CID: 133081964

Item Number

J611234

Grouped product items
SKU	Size	Availability	Price	Qty
J611234-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
J611234-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

cyclin dependent kinase 19 Inhibitor cyclin dependent kinase 8 Inhibitor

Basic Description

Synonyms	compound 19 [Hatcher et al., 2018]
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase 19;Inhibitor of cyclin dependent kinase 8

Associated Targets

CDK8 Tchem Cyclin-dependent kinase 8 1 Activities

Discover Target: CDK8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK19 Tchem Cyclin-dependent kinase 19 1 Activities

Discover Target: CDK19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C30H40N2/c1-29-14-11-24(32(3)4)18-23(29)7-8-25-27-10-9-26(30(27,2)15-12-28(25)29)21-6-5-20-13-16-31-19-22(20)17-21/h5-7,13,16-17,19,24-28H,8-12,14-15,18H2,1-4H3/t24-,25-,26+,27-,28?,29-,30+/m0/s1
InChi Key	IWZSHWBGHQBIML-ZGGLMWTQSA-N
Canonical SMILES	CN([C@H]1CC[C@]2(C(=CC[C@@H]3C2CC[C@]2([C@H]3CC[C@@H]2c2ccc3c(c2)cncc3)C)C1)C)C
PubChem CID	133081964

Database links

PubChem CID	133081964

Certificates

Certificate of Analysis(COA)

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References

1. Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. (2018) Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.. ACS Med Chem Lett, 9 (6): (540-545). [PMID:29937979]

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