JI051 - ≥98.0%, high purity , CAS No.2234281-75-3

Item Number

J648404

Grouped product items
SKU	Size	Availability	Price
J648404-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
J648404-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
J648404-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,250.90
J648404-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,500.90

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Basic Description

Specifications & Purity	≥98.0%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity. In Vitro JI051 causes G2/M cell-cycle arrest. JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC 50 of 0.3 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: HEK293 cells Concentration: 0.1-10 µM Incubation Time: 24 hours Result: Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations. Form:Solid

Names and Identifiers

IUPAC Name	(E)-N-[2-(2-ethoxyphenyl)ethyl]-3-(7-methoxy-1H-indol-3-yl)prop-2-enamide
INCHI	InChI=1S/C22H24N2O3/c1-3-27-19-9-5-4-7-16(19)13-14-23-21(25)12-11-17-15-24-22-18(17)8-6-10-20(22)26-2/h4-12,15,24H,3,13-14H2,1-2H3,(H,23,25)/b12-11+
InChi Key	CQZPBIZGVIRKOC-VAWYXSNFSA-N
Canonical SMILES	CCOC1=CC=CC=C1CCNC(=O)C=CC2=CNC3=C2C=CC=C3OC
PubChem CID	138319697
Molecular Weight	364.44

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Basic Description