JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition
In Vitro
JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability. JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: LOX-IMVI cells Concentration: 0~100 nΜ Incubation Time: 72 hours Result: Inhibited cell viability.
