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JNJ-10191584 , CAS No.73903-17-0, Antagonist of H 4 receptor

  • Moligand™
Item Number
J611253
Grouped product items
SKUSizeAvailabilityPrice Qty
J611253-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
J611253-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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H4 receptor Antagonist

Basic Description

SynonymsJNJ-10191584|73903-17-0|JNJ 10191584|jnj10191584|VUF-6002|(5-chloro-1H-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone|7EE5T3WL8P|CHEMBL185951|JNJ 10191584 (maleate)|VUF 6002|Methanone, (6-chloro-1H-benzimidazol-2-yl)(4-methyl-1-piperazinyl)-|Piperazi
Specifications & PurityMoligand™
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of H 4 receptor

Associated Targets

HRH4 Tchem Histamine H4 receptor 11 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (6-chloro-1H-benzimidazol-2-yl)-(4-methylpiperazin-1-yl)methanone
INCHI InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16)
InChi Key MOIWSUQWIOVGRH-UHFFFAOYSA-N
Canonical SMILES CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl
Isomeric SMILES CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl
Alternate CAS 73903-17-0
PubChem CID 10446295
MeSH Entry Terms VUF 6002;VUF-6002;VUF6002

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Terzioglu N, van Rijn RM, Bakker RA, De Esch IJ, Leurs R.  (2004)  Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists..  Bioorg Med Chem Lett,  14  (21): (5251-6).  [PMID:15454206]
2. Venable JD, Cai H, Chai W, Dvorak CA, Grice CA, Jablonowski JA, Shah CR, Kwok AK, Ly KS, Pio B et al..  (2005)  Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists..  J Med Chem,  48  (26): (8289-98).  [PMID:16366610]

Solution Calculators

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